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Lipid Phosphate Phosphohydrolase 2 (PPAP2C) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395724

Phosphatidic acid (PA), lysophosphatidic acid, ceramide 1-phosphate (C1P), and sphingosine 1-phosphate (S1P) are lipid mediators generated by phospholipases, sphingomyelinases, and lipid kinases. The major pathway for degradation of these lipids is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Lipid Phosphate Phosphohydrolase 2 (PPAP2C), Polyclonal Antibody
Full Product Name
Lipid Phosphate Phosphohydrolase 2
Product Gene Name
Product Synonym Names
Pan Phosphatidic Acid Phosphatase 2C; Pan PPAP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Porcine
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purity/Purification
Antigen Immunoaffiinity Purification
Preparation and Storage
Product should be stored at -70 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
32.5
Chromosome Location
Chromosome: 19; NC_000019.9 (281043..291435, complement). Location: 19p13
OMIM
607126
3D Structure
ModBase 3D Structure for O43688
Immunogen
Synthetic peptide derived from the lipid phosphate phosphohydrolase 2 protein
Positive Control
Human brain lysate
Applications Tested/Suitable for anti-PPAP2C antibody
Western Blot (WB), ELISA (EIA)

Western Blot/Blotting of anti-PPAP2C antibody

Western blot analysis using Pan PPAP antibody on human brain lysate.
Rabbit Anti-PPAP2C Polyclonal Antibody – Cat# MBS395724

Other Notes

Small volumes of anti-PPAP2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPAP2C purchase

MBS395724 is an antibody targeting PPAP2C. Also known as Lipid Phosphate Phosphohydrolase 2. Reactive in Human, Porcine. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPAP2C. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
lipid phosphate phosphohydrolase 2 isoform 1
NCBI Official Synonym Full Names
phosphatidic acid phosphatase type 2C
NCBI Official Symbol
PPAP2C
NCBI Official Synonym Symbols
LPP2; PAP-2c; PAP2-g
UniProt Protein Name
Lipid phosphate phosphohydrolase 2
UniProt Synonym Protein Names
PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c
UniProt Gene Name
PPAP2C
UniProt Synonym Gene Names
LPP2; PAP2-G; PAP-2c; PAP2c
UniProt Entry Name
LPP2_HUMAN
NCBI Protein Information
lipid phosphate phosphohydrolase 2; PAP2c; PAP2-gamma; phosphatidic acid phosphatase 2c; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma

NCBI Summary for PPAP2C

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for PPAP2C

Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulation: Inhibited by sphingosine, zinc ions and propanolol.

Subunit structure: Homodimer

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Found mainly in brain, pancreas and placenta.

Sequence similarities: Belongs to the PA-phosphatase related phosphoesterase family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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