Flip (I-Flice) (Flice Inhibitory Protein) (CASP8AP2) Antibody – Rabbit Polyclonal

Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation

By similarity. Required for histone gene transcription and progression through S phase

By similarity. Required for histone gene transcription and S phase progression

By similarity. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Ref.1 Ref.5 Ref.6 UniProtKB Q9UKL3

Subunit structure: Self-associates. Interacts with NPAT

By similarity. Interacts with SRRT

By similarity. Interacts (via SIM domains) with SUMO1 and SUMO2

By similarity. Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm

By similarity. Interacts with NCOA2 and NCOA3

By similarity. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with TRAF2. Ref.1 Ref.5 Ref.8

Subcellular location: Cytoplasm

By similarity. Nucleus. Nucleus › PML body

By similarity. Mitochondrion

By similarity. Note: Exported from the nucleus to the mitochondria upon FAS activation

By similarity. Ref.7

Tissue specificity: Highly expressed in heart, brain, thymus, lung, testis and spleen. Ref.1