Protein Phosphatase V/C (PP6C) Antibody – Sheep Polyclonal

Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Ref.1 Ref.2 Ref.11 Ref.12

Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.

Cofactor: Binds 1 iron ion per subunit

By similarity.Binds 1 manganese ion per subunit

By similarity.

Subunit structure: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3. Ref.9 Ref.10 Ref.11 Ref.13

Subcellular location: Cytoplasm Ref.10 Ref.12.

Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. Ref.1 Ref.10

Induction: Regulated by IL2/interleukin-2 in peripheral blood T cells. Ref.2

Sequence similarities: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.