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Lass1 (Cross Reacts with GDF1) (GDF1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395829

LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may… More details

$500 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Lass1 (Cross reacts with GDF1), Polyclonal Antibody
Full Product Name
Lass1 (Cross reacts with GDF1)
Product Gene Name
Product Synonym Names
LAG1 longevity assurance homolog 1; UOG-1 protein; LAG1; LASS1; LAG1 longevity assurance homolog 1 (LASS 1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purity/Purification
Antigen Immunoaffiinity Purification
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
39.5 kDa
Chromosome Location
Chromosome: 19; NC_000019.9 (18979361..19006953, complement). Location: 19p12
OMIM
606919
3D Structure
ModBase 3D Structure for P27544
Immunogen
Synthetic peptide derived from the human Lass1 protein.
Positive Control
Hypothalamus
Applications Tested/Suitable for anti-GDF1 antibody
Western Blot (WB)

Western Blot/Blotting of anti-GDF1 antibody

Western blot analysis using LAG1 longevity assurance homolog 1 at 5 ug/ml on human brain lysate 14 ug/lane . Lane A] antibody alone, Lane B] antibody with 45ug blocking peptide, Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution . Exposure for 5 min
Rabbit Anti-GDF1 Polyclonal Antibody – Cat# MBS395829

Other Notes

Small volumes of anti-GDF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF1 purchase

MBS395829 is an antibody targeting GDF1. Also known as Lass1 (Cross reacts with GDF1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ceramide synthase 1 isoform 1
NCBI Official Synonym Full Names
ceramide synthase 1
NCBI Official Symbol
CERS1
NCBI Official Synonym Symbols
LAG1; UOG1; LASS1
UniProt Protein Name
Ceramide synthase 1
UniProt Synonym Protein Names
LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1
UniProt Gene Name
CERS1
UniProt Synonym Gene Names
LAG1; LASS1; UOG1; CerS1
UniProt Entry Name
CERS1_HUMAN
NCBI Protein Information
ceramide synthase 1; protein UOG-1; upstream of GDF1; longevity assurance gene 1 protein homolog 1; longevity assurance (LAG1, S. cerevisiae) homolog 1

NCBI Summary for GDF1

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]
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UniProt Comments for GDF1

Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity. Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity. Golgi apparatus membrane; Multi-pass membrane protein

By similarity. Note: Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.

Miscellaneous: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.

Sequence similarities: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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