PINK1 Antibody – Rabbit Polyclonal

Function: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Ref.2 Ref.7 Ref.8 Ref.9 Ref.16

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Cofactor: Magnesium. Ref.2

Subunit structure: Interacts with PARK2. Ref.7 Ref.9

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm › cytosol Ref.6 Ref.7 Ref.16.

Tissue specificity: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Ref.1

Post-translational modification: Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PARK2 recruitment to depolarized mitochondria.

Involvement in disease: Parkinson disease 6 (PARK6) [MIM:605909]: A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.11 Ref.12 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.31

Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.