Sheep Anti-DAB1 Polyclonal Antibody – Cat# MBS395918

Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts.

Disabled (DAB1) Antibody – Sheep Polyclonal

Name: DAB1 Antibody; Polyclonal; Sheep; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395918
Price: 500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395918

Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It… More details

$500 / 0.25 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Disabled (Dab1), Polyclonal Antibody

Full Product Name

Disabled (NT)

Product Gene Name

anti-Dab1 antibody

Product Synonym Names

Disabled homolog 1; DAB1

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Mouse

Form/Format

Provided as 0.2mm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.

Purity/Purification

Ammonium Sulfate Precipitation

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

Chromosome Location

Chromosome: 4; NC_000070.6 (104367560..104744842). Location: 4 C6; 4 47.79 cM

3D Structure

ModBase 3D Structure for P97318

Immunogen

Recombinant protein corresponding to amino acids 1-179 of mouse disabled coupled to a GST fusion protein.

Positive Control

293 cells transfected with Dab-1 HA tag

Product Categories/Family for anti-Dab1 antibody

Polyclonal Antibody; Neuronal Signaling

Applications Tested/Suitable for anti-Dab1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-Dab1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dab1 purchase

MBS395918 is an antibody targeting Dab1. Also known as Disabled (NT). Reactive in Mouse. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for Dab1. It may not necessarily be applicable to this product.

NCBI GI #

6753596

NCBI GeneID

13131

NCBI Accession #

NP_034144.1

UniProt Primary Accession #

P97318

UniProt Secondary Accession #

P97316; P97317; Q9DAP9; A2A963; A2A964; A2A965; A2A966; A2A967; A2A970

UniProt Related Accession #

P97318

GenBank Nucleotide #

NM_010014.2

NCBI Official Full Name

disabled homolog 1 isoform 1

NCBI Official Synonym Full Names

disabled 1

NCBI Official Symbol

Dab1

NCBI Official Synonym Symbols

scm; scr; yot; AI956902; scrambler; C630028C02Rik

UniProt Protein Name

Disabled homolog 1

Protein Family

Disabled

UniProt Gene Name

Dab1

UniProt Entry Name

DAB1_MOUSE

NCBI Protein Information

disabled homolog 1; yotari

UniProt Comments for Dab1

Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. Ref.1

Subunit structure: Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR. Interacts with APLP1 (via NPXY motif). Ref.1 Ref.7 Ref.8 Ref.9 Ref.10

Tissue specificity: Expressed mainly in brain. Ref.1

Domain: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Post-translational modification: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (Ref.5). Also found phosphorylated on Tyr-232 upon reelin induction (Ref.8). Also phosphorylated on Ser-524 independently of reelin signaling. Ref.4 Ref.5 Ref.6 Ref.8

Sequence similarities: Contains 1 PID domain.

Research Articles on Dab1

1. Reeler and scrambler (Dab1) mutant neurites extend tangentially rather than radially, and the Golgi apparatus that normally invests the apical neurite is compact in both reeler and scrambler mutants.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Dab1 antibody

Products by Pathway	Pathway Diagram
Splicing Factor NOVA Regulated Synpatic Proteins Pathway antibodies	Splicing Factor NOVA Regulated Synpatic Proteins Pathway Diagram

Diseases associated with anti-Dab1 antibody

Disease Name	Pubmed Publications
Movement Disorders Antibodies	>9 publications with Dab1 and Movement Disorders
Disease Models, Animal Antibodies	>4 publications with Dab1 and Disease Models, Animal
Pain Antibodies	>3 publications with Dab1 and Pain
Neoplasms, Experimental Antibodies	>3 publications with Dab1 and Neoplasms, Experimental
Inflammation Antibodies	>2 publications with Dab1 and Inflammation
Mood Disorders Antibodies	>2 publications with Dab1 and Mood Disorders
Abnormalities, Drug-Induced Antibodies	>1 publications with Dab1 and Abnormalities, Drug-Induced
Microcephaly Antibodies	>1 publications with Dab1 and Microcephaly
Neurobehavioral Manifestations Antibodies	>1 publications with Dab1 and Neurobehavioral Manifestations
Breast Neoplasms Antibodies	>1 publications with Dab1 and Breast Neoplasms

Organs/Tissues associated with anti-Dab1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>229 publications with Dab1 and Brain
Embryonic Tissue Antibodies	>72 publications with Dab1 and Embryonic Tissue
Spinal Cord Antibodies	>14 publications with Dab1 and Spinal Cord
Eye Antibodies	>14 publications with Dab1 and Eye
Kidney Antibodies	>6 publications with Dab1 and Kidney
Intestine Antibodies	>4 publications with Dab1 and Intestine
Spleen Antibodies	>3 publications with Dab1 and Spleen
Ovary Antibodies	>1 publications with Dab1 and Ovary