Phosphatidic Acid Phosphatase 2b (PPAP2B) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulation: Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.

Subunit structure: Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability. Ref.9

Subcellular location: Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta.

Induction: By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA). Ref.1

Post-translational modification: N-glycosylated. Contains high-mannose oligosaccharides.

Sequence similarities: Belongs to the PA-phosphatase related phosphoesterase family.

Sequence caution: The sequence AAB50222.1 differs from that shown. Reason: Frameshift at position 225.