Rabbit Anti-Bnip3L Polyclonal Antibody – Cat# MBS396006

Western blot analysis

Bnip3L Antibody – Rabbit Polyclonal

Name: Bnip3L Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS396006
Price: 720 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS396006

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Bnip3L (nix) (bcl 2 family), Polyclonal Antibody

Full Product Name

Bnip3L (IN) (nix) (bcl 2 family)

Product Gene Name

anti-Bnip3L antibody

Product Synonym Names

BNIP3A; BNIP3H; NIX

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Purity/Purification

Antigen Immunoaffiinity Purification

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

Chromosome Location

Chromosome: 8; NC_000008.10 (26240523..26270644). Location: 8p21

OMIM

605368

3D Structure

ModBase 3D Structure for O60238

Immunogen

Synthetic peptide corresponding to amino acids 77 to 92 of the human Bnip3L protein. Immunogen sequence is identical in the mouse protein.

Positive Control

K562 cell lysate

Product Categories/Family for anti-Bnip3L antibody

Polyclonal Antibody; Bcl-2 Family

Applications Tested/Suitable for anti-Bnip3L antibody

Western Blot (WB)

Other Notes

Small volumes of anti-Bnip3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bnip3L purchase

MBS396006 is an antibody targeting Bnip3L. Also known as Bnip3L (IN) (nix) (bcl 2 family). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bnip3L. It may not necessarily be applicable to this product.

NCBI GI #

4757860

NCBI GeneID

665

NCBI Accession #

NP_004322.1

UniProt Primary Accession #

O60238

UniProt Secondary Accession #

Q5JW63; Q8NF87

UniProt Related Accession #

O60238

GenBank Nucleotide #

NM_004331.2

NCBI Official Full Name

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

NCBI Official Synonym Full Names

BCL2/adenovirus E1B 19kDa interacting protein 3-like

NCBI Official Symbol

BNIP3L

NCBI Official Synonym Symbols

NIX; BNIP3a

UniProt Protein Name

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

UniProt Synonym Protein Names

Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X

Protein Family

BCL2/adenovirus E1B 19 kDa protein-interacting protein

UniProt Gene Name

BNIP3L

UniProt Synonym Gene Names

BNIP3A; BNIP3H; NIX; NIP3L

UniProt Entry Name

BNI3L_HUMAN

NCBI Protein Information

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

NCBI Summary for Bnip3L

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]

UniProt Comments for Bnip3L

Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. Ref.4 Ref.13

Subunit structure: Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Ref.4 Ref.10 Ref.13

Subcellular location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein

Potential. Note: Colocalizes with SPATA18 at the mitochondrion outer membrane. Ref.4 Ref.13

Post-translational modification: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.

Sequence similarities: Belongs to the NIP3 family.

Sequence caution: The sequence CAI46217.1 differs from that shown. Reason: Erroneous termination at position 122. Translated as Glu.

Research Articles on Bnip3L

1. Nix protein positively regulates NF-kappaB activation in gliomas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Bnip3L antibody

Reference Product	PubMed Publications
BNIP3 antibody	>83 publications with Bnip3L and BNIP3
HIF1A antibody	>18 publications with Bnip3L and HIF1A
BCL2 antibody	>17 publications with Bnip3L and BCL2
BCL2L1 antibody	>13 publications with Bnip3L and BCL2L1
TP53 antibody	>3 publications with Bnip3L and TP53
ERBB2 antibody	>2 publications with Bnip3L and ERBB2
CREBBP antibody	>1 publications with Bnip3L and CREBBP

Pathways associated with anti-Bnip3L antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram

Diseases associated with anti-Bnip3L antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>54 publications with Bnip3L and Neoplasms
Necrosis Antibodies	>14 publications with Bnip3L and Necrosis
Breast Neoplasms Antibodies	>13 publications with Bnip3L and Breast Neoplasms
Heart Diseases Antibodies	>13 publications with Bnip3L and Heart Diseases
Cardiovascular Diseases Antibodies	>13 publications with Bnip3L and Cardiovascular Diseases
Cardiomyopathies Antibodies	>6 publications with Bnip3L and Cardiomyopathies
Nervous System Diseases Antibodies	>6 publications with Bnip3L and Nervous System Diseases
Brain Diseases Antibodies	>5 publications with Bnip3L and Brain Diseases
Liver Neoplasms Antibodies	>5 publications with Bnip3L and Liver Neoplasms
Neoplasm Metastasis Antibodies	>5 publications with Bnip3L and Neoplasm Metastasis

Organs/Tissues associated with anti-Bnip3L antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>19 publications with Bnip3L and Heart
Blood Antibodies	>17 publications with Bnip3L and Blood
Muscle Antibodies	>14 publications with Bnip3L and Muscle
Liver Antibodies	>9 publications with Bnip3L and Liver
Lung Antibodies	>8 publications with Bnip3L and Lung
Vascular Antibodies	>8 publications with Bnip3L and Vascular
Brain Antibodies	>6 publications with Bnip3L and Brain
Kidney Antibodies	>5 publications with Bnip3L and Kidney
Prostate Antibodies	>4 publications with Bnip3L and Prostate
Skin Antibodies	>3 publications with Bnip3L and Skin