Protein Phosphatase 2 B Alpha (Calcineurin) (PPP3CA) Antibody – Rabbit Polyclonal

Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. Ref.12 Ref.13

Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.

Cofactor: Binds 1 Fe3+ ion per subunit.Binds 1 zinc ion per subunit.

Subunit structure: Interacts with CHP1 and CHP2

By similarity. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle

By similarity. Ref.9 Ref.10 Ref.11 Ref.13

Subcellular location: Nucleus

By similarity. Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle

By similarity.

Sequence similarities: Belongs to the PPP phosphatase family. PP-2B subfamily.