Mouse Anti-CD54 Antibody – Cat# MBS396523

Peripheral blood lymphocytes stained with CD54 PE Conjugated Antibody.

CD54 Antibody – Mouse

Name: CD54 Antibody; Mouse; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS396523
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS396523

CD54, M.W. 90,000, antigen is the Intercellular Adhesion Molecule-1 (ICAM-1) and is the ligand for LFA-1 mediated adhesion. CD54 is weakly expressed on peripheral blood leukocytes. Upon activation the antigen is expressed strongly on B cells, T cells,… More details

$370 / 100 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD54, Antibody

Full Product Name

CD54 Biotin

Product Gene Name

anti-CD54 antibody

Product Synonym Names

CD54Biotin

Isotype

IgG2b

Clone Number

D3.6

Host

Mouse

Species Reactivity

Human

Form/Format

Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein

Purity/Purification

Protein A/G Chromatography

Preparation and Storage

Product should be stored at 4-8 degree C. DO NOT FREEZE

Molecular Weight

57,825 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (10381517..10397291). Location: 19p13.3-p13.2

OMIM

147840

3D Structure

ModBase 3D Structure for P05362

Immunogen

CD54=Derived from the hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with the major histocompatibility complex (MHC) class II-negative human b-lymphoblastoid cell line 6.16c13

Product Categories/Family for anti-CD54 antibody

Single-Color Reagent; Single Color Markers

Applications Tested/Suitable for anti-CD54 antibody

Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-CD54 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD54 purchase

MBS396523 is an antibody targeting CD54. Also known as CD54 Biotin. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD54. It may not necessarily be applicable to this product.

NCBI GI #

167466198

NCBI GeneID

3383

NCBI Accession #

NP_000192.2

UniProt Primary Accession #

P05362

UniProt Secondary Accession #

Q5NKV7; Q96B50; B2R6M3

UniProt Related Accession #

P05362

GenBank Nucleotide #

NM_000201.2

NCBI Official Full Name

intercellular adhesion molecule 1

NCBI Official Synonym Full Names

intercellular adhesion molecule 1

NCBI Official Symbol

ICAM1

NCBI Official Synonym Symbols

BB2; CD54; P3.58

UniProt Protein Name

Intercellular adhesion molecule 1

UniProt Synonym Protein Names

Major group rhinovirus receptor

Protein Family

Intercellular adhesion molecule

UniProt Gene Name

ICAM1

UniProt Synonym Gene Names

ICAM-1

UniProt Entry Name

ICAM1_HUMAN

NCBI Protein Information

intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

NCBI Summary for CD54

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for CD54

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Ref.12 Ref.13 Ref.14 Ref.18

Subunit structure: Homodimer

Probable. Interacts with human herpesvirus 8 MIR2 protein

Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Ref.14 Ref.15 Ref.18 Ref.28 Ref.29

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Polymorphism: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [

MIM:611162].

Sequence similarities: Belongs to the immunoglobulin superfamily. ICAM family.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Research Articles on CD54

1. Atorvastatin significantly prevents atherosclerotic changes in rabbits with a high-cholesterol diet, possibly by lowering plasma lipids and decreasing over-expressed ICAM-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD54 antibody

Reference Product	PubMed Publications
ITGB2 antibody	>860 publications with CD54 and ITGB2
ITGAL antibody	>467 publications with CD54 and ITGAL
ITGAM antibody	>423 publications with CD54 and ITGAM
CD44 antibody	>356 publications with CD54 and CD44
ITGAX antibody	>134 publications with CD54 and ITGAX
IL6 antibody	>115 publications with CD54 and IL6
SELE antibody	>59 publications with CD54 and SELE
HLA-B antibody	>28 publications with CD54 and HLA-B
DIF antibody	>3 publications with CD54 and DIF

Pathways associated with anti-CD54 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD54 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>5055 publications with CD54 and Inflammation
Necrosis Antibodies	>4429 publications with CD54 and Necrosis
Cardiovascular Diseases Antibodies	>3292 publications with CD54 and Cardiovascular Diseases
Atherosclerosis Antibodies	>1304 publications with CD54 and Atherosclerosis
Reperfusion Injury Antibodies	>809 publications with CD54 and Reperfusion Injury
Myocardial Ischemia Antibodies	>738 publications with CD54 and Myocardial Ischemia
Kidney Diseases Antibodies	>717 publications with CD54 and Kidney Diseases
Liver Diseases Antibodies	>511 publications with CD54 and Liver Diseases
Asthma Antibodies	>473 publications with CD54 and Asthma
Hypertension Antibodies	>472 publications with CD54 and Hypertension

Organs/Tissues associated with anti-CD54 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11050 publications with CD54 and Blood
Vascular Antibodies	>8209 publications with CD54 and Vascular
Lung Antibodies	>1630 publications with CD54 and Lung
Heart Antibodies	>1177 publications with CD54 and Heart
Skin Antibodies	>1165 publications with CD54 and Skin
Liver Antibodies	>1106 publications with CD54 and Liver
Kidney Antibodies	>1097 publications with CD54 and Kidney
Brain Antibodies	>1084 publications with CD54 and Brain
Muscle Antibodies	>956 publications with CD54 and Muscle
Embryonic Tissue Antibodies	>754 publications with CD54 and Embryonic Tissue