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Calretinin (CALB2) Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS397035

The antibody is suitable for the detection of Calretinin in neurons and may be used as an aid in differential identification of pleura-mesothelioma. This marker is frequently expressed in epitheloid mesothelioma, while occasionally it turns positive in… More details

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Product Overview

Online Datasheet in PDF
Product Name
Calretinin (CALB2), Antibody
Full Product Name
Calretinin, monoclonal
Product Gene Name
Isotype
ig
Clone Number
6B3
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide.
Preparation and Storage
Store at 2-8 degree C.
Molecular Weight
31,540 Da
3D Structure
ModBase 3D Structure for P22676
Immunogen
Recombinant human Calretinin 22kDa
Positive Control
Cerebral cortex, pleural mesothelioma
Incubation Time
60 min at RT
Pre-Treatment
Improvement of staining with Unmasking Fluid G () or Unmasking Fluid C
Applications Tested/Suitable for anti-CALB2 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Immunoblotting (IB)
Application Notes for anti-CALB2 antibody
Dilution: 1:40-1:50

Product References and Citations for anti-CALB2 antibody

1. Schwaller B., Buchwald P., Blümcke I., Celio M.R., and Hunziker W. (1994) Charakterization of a polyclonal antiserum against the purified human recombinant calcium binding protein calretinin. Cell Calcium 14; 639-648. 2. Gotzos V., Vogt P., and Celio M.R. (1995) Calretinin is a selective marker for malignant pleural mesotheliomas of the epithelial type. Pathol. Res. Pract. 192; 137-147. 3. Doglioni C., Tos A.P., Laurino L., Iuzzolino P., Chiarelli C., Celio M.R., and Viale G. (1996) Calretinin: a novel immunohistochemical marker for mesothelioma. Am. J. Surg. Pathol. 20; 1037-1046. 4. Zimmermann L., and Schwaller B. (2002) Monoclonal antibodies recognizing epitopes of calretinins: dependence on Ca2+-binding status and differences in antigen accessibility in colon cancer cells. Cell Calcium 31; 13-25.

Other Notes

Small volumes of anti-CALB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALB2 purchase

MBS397035 is an antibody targeting CALB2. Also known as Calretinin, monoclonal. Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CALB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calretinin isoform 1
NCBI Official Synonym Full Names
calbindin 2
NCBI Official Symbol
CALB2
NCBI Official Synonym Symbols
CR; CAL2; CAB29
UniProt Protein Name
Calretinin
UniProt Synonym Protein Names
29 kDa calbindin
Protein Family
UniProt Gene Name
CALB2
UniProt Synonym Gene Names
CAB29; CR
NCBI Protein Information
calretinin

NCBI Summary for CALB2

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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UniProt Comments for CALB2

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Research Articles on CALB2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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