Pan-Cytokeratin Antibody – Mouse

Pan-Cytokeratin (AE1/AE3) contains two different clones, which label the majority of normal epithelia and carcinoma. Cytokeratins are a group of water soluble filament proteins, which are components of the cytoskeleton of the epidermis and other epithelial cells. Gelelectrophoretic investigation revealed 20 different Cytokeratins, characterised by different molecular sizes and pI-values. They can be subdivided into basic and acid subfamilies. The nomenclature according to Moll et al. (1982) is most commonly used. Basic cytokeratins (52-67 kD) and acid cytokeratins (40, 48, 50, 50', 56,5 kD) CK 1-8, 10, 14-16 and 19 according to the nomenclature by Moll (1982).

1. Moll R., Franke W.W., Schiller D.L., Geiger B., and Krepler R. (1982) The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelia, Tumors and Cultured Cells. Cell 31; 11 ff. 2. Sun T.-T. Tseng S.C.G., Huang A.J.W., Cooper D., Lynch M.H., Weiss R., Eichner R., and Schermer (1985) Monoclonal antibody studies of keratin expression: A review. In: Intermediate Filaments, Wang E. et al. eds. N.Y. Acad. Sci. 455, pp 307 ff.

Small volumes of anti-Pan-Cytokeratin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS397074 is an antibody targeting Pan-Cytokeratin. Also known as Pan-Cytokeratin, 2 Clones (AE1/AE3). Reactive in Human, Chicken, Cattle, Rabbit, Mouse, Rat. Host: Mouse.