Cytokeratin 10 Antibody – Mouse

CK10 stains supra-basal cells in the epidermis and in different squamous epithelia of internal organs (vagina, exocervix, tongue, palate). In skin cells of sweat glands and hair roots are labelled. Simple epithelia, glandular epithelia and transitional epithelia of the urinary tract are negative. The antibody may be used for differential identification of squamous epithelial carcinoma, which are Cytokeratin 10 positive, while adenocarcinoma are negative. Cytokeratins are a group of water insoluble filament proteins, which are constituents of the cytoskeleton of epidermal cells and other epithelial cells. By gel electrophoretic analysis up to now 20 different cytokeratins have been characterized. They have been divided into basic and acid subfamilies and may also be distinguished by their molecular weights and their tissue distribution. The most frequently used nomenclature has been published by R. Moll et al. (1982). 56,5 kDa Cytokeratin according to CK10 (Moll et al. 1982).

1. Moll R., Franke W.W., Schiller D.L., Geiger B., and Krepler R. (1982) The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelia, Tumors and Cultured Cells. Cell 31; 11 ff. 2. Ivanyi D., Ansink A., Groeneveld E., Hageman P.C., Mooi W.J., and Heintz A.P.M. (1989) New monoclonal antibodies recognizing epidermal differentiation-associated keratins in formalin-fixed, paraffin-embedded tissue. Keratin 10 expression in carcinoma of the vulva. J. Pathol. 159; 7-12. 3. Ivanyi D., Groeneveld E., Van Doornewaard G., Mooi W.J., and Hageman P.C. (1990) Keratin subtypes in carcinomas of the uterin cervix: implications for histiogenesis and differential diagnosis. Cancer Res. 50; 5143-5152. 4. Mommers JM, van Rossum MM, van Erp PE, van De Kerkhof PC. (2000) Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. Dermatology 2000;201(1):15-20.

Small volumes of anti-Cytokeratin 10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS397078 is an antibody targeting Cytokeratin 10. Reactive in Human, Cattle, Rat. Host: Mouse.