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Collagen Type III (COL3A1) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS397130

Type III collagen is an alpha1(III)-trimer, which forms 67 nm cross-banded fibrils. Typically it can be observed in skin, cartilage and vitreous body. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct… More details

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Product Overview

Online Datasheet in PDF
Product Name
Collagen Type III (Col3a1), Antibody
Full Product Name
Collagen Type III, rat
Product Gene Name
anti-Col3a1 antibody
Host
Rabbit
Species Reactivity
Rat, Mouse
Form/Format
Lyophilized from phosphate buffered solution; no BSA and preservative added.
Purity/Purification
Affinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C.
Molecular Weight
138,936 Da
3D Structure
ModBase 3D Structure for P13941
Immunogen
Purified collagen type III from rat skin
Positive Control
Rat skin or liver
Incubation Time
IHC(P) 60 min at RT or 2-8 degree C over night
Pre-Treatment
After de-waxing the tissue slices they are treated with 0.2% hyaluronidase (app. 300 U/mg) in TBS 15 min at 37 degree C. Thereafter non-specific binding is blocked by blocking serum or 3% BSA in TBS. For peroxidase systems blocking with 1% peroxide solution in TBS for 30 min at RT is recommended.
Applications Tested/Suitable for anti-Col3a1 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA), Radioimmunoassay (RIA)
Application Notes for anti-Col3a1 antibody
IFA: 1:80
IHC-P: 1:500
ELISA: 1:200

Product References and Citations for anti-Col3a1 antibody

1. Bouvier M., Couble M.L., Hartmann D.J., Magloire H. (1991) Isolation and characterization of rat alveolar bone cells. Cell Mol. Biol. 37, 509-517. 2. Breen E., Falco V.M., Absher M., Cutroneo K.R. (1990) Subpopulations of rat lung fibroblasts with different amounts of type I and type III collagen mRNAs. J. Biol. Chem. 265, 6286-6290. 3. Vialle-Presles M.J., Hartmann D.J., Franc S., Herbage D. (1989) Immunohistochemical study of the biological fate of a subcutaneous bovine collagen implant in rat. Histochemistry 91, 177-184. 4. Al Adnani M.S. (1989) Differential immunohistochemical localization of cytokeratins and collagen types I and III in experimentally-induced cirrhosis. J. Pathol. 159, 151-158.

Other Notes

Small volumes of anti-Col3a1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Col3a1 purchase

MBS397130 is an antibody targeting Col3a1. Also known as Collagen Type III, rat. Reactive in Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Col3a1. It may not necessarily be applicable to this product.

NCBI GI #
56711254
NCBI GeneID
84032
NCBI Accession #
NP_114474.1
UniProt Primary Accession #
P13941
UniProt Secondary Accession #
O70604; Q5PQT6
UniProt Related Accession #
P13941
GenBank Nucleotide #
NM_032085.1
NCBI Official Full Name
collagen alpha-1(III) chain
NCBI Official Synonym Full Names
collagen type III alpha 1 chain
NCBI Official Symbol
Col3a1
UniProt Protein Name
Collagen alpha-1(III) chain
Protein Family
Collagen
UniProt Gene Name
Col3a1
NCBI Protein Information
collagen alpha-1(III) chain

NCBI Summary for Col3a1

may be involved in craniofacial development [RGD, Feb 2006]

UniProt Comments for Col3a1

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 ().
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Research Articles on Col3a1

1. the diagnostic value of urinary collagen degradation products in a proteinuria-driven fibrosis rat model, was investigated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Col3a1 antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram

Diseases associated with anti-Col3a1 antibody

 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >129 publications with Col3a1 and Vascular Diseases
 Ehlers Danlos syndrome type 4, autosomal dominant Antibodies  >122 publications with Col3a1 and Ehlers Danlos syndrome type 4, autosomal dominant
 Genetic Diseases, Inborn Antibodies  >111 publications with Col3a1 and Genetic Diseases, Inborn
 Hematologic Diseases Antibodies  >101 publications with Col3a1 and Hematologic Diseases
 Fibrosis Antibodies  >35 publications with Col3a1 and Fibrosis
 Abnormalities, Multiple Antibodies  >18 publications with Col3a1 and Abnormalities, Multiple
 Wounds and Injuries Antibodies  >18 publications with Col3a1 and Wounds and Injuries
 Neoplasms Antibodies  >17 publications with Col3a1 and Neoplasms
 Aortic Aneurysm Antibodies  >16 publications with Col3a1 and Aortic Aneurysm
 Inflammation Antibodies  >14 publications with Col3a1 and Inflammation

Organs/Tissues associated with anti-Col3a1 antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >69 publications with Col3a1 and Connective Tissue
 Artery Antibodies  >46 publications with Col3a1 and Artery
 Muscle Antibodies  >44 publications with Col3a1 and Muscle
 Heart Antibodies  >21 publications with Col3a1 and Heart
 Lung Antibodies  >18 publications with Col3a1 and Lung
 Kidney Antibodies  >11 publications with Col3a1 and Kidney
 Colon Antibodies  >11 publications with Col3a1 and Colon
 Embryonic Tissue Antibodies  >11 publications with Col3a1 and Embryonic Tissue
 Brain Antibodies  >9 publications with Col3a1 and Brain
 Liver Antibodies  >6 publications with Col3a1 and Liver
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