Collagen Type IV Antibody – Rabbit

Type IV Collagen is a non-fibrillary network of different alpha-chains: alpha 1(IV) to-alpha 6(IV). It is typically found in basal membranes of different organs (e.g. skin, lens, lung, kidney). Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs. Rat collagen type IV 100%; rat collagen type I, II, III and V <0.1%; rat fibronectin <0.1%; murine laminin <0.1% (RIA at 1:5000 dilution).

1. Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, Deguchi K, Abe K (2014) Neurovascular Protection by Telmisartan via Reducing Neuroinflammation in Stroke-Resistant Spontaneously Hypertensive Rat Brain after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2014 Dec 19. pii: S1052-3057(14)00498-4.

Small volumes of anti-Collagen Type IV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS397134 is an antibody targeting Collagen Type IV. Also known as Collagen Type IV, rat. Reactive in Rat, Human collagen type IV (<0.1%). Host: Rabbit.