Neuronal Cell Adhesion Molecule (N-CAM) Antibody – Mouse

Antibody RNL-1 shows heavy N-CAM expression on cells of the small cell lung carcinoma (SCLC), neuroblastoma, nerves, Leydig-cells, thyroid epithelia and parafollikular cells, pancreas islet cells, adrenal cortex and medulla, and hypophysis. Little differentiated squamous lung tumours may by RNL-1 positive, while adenocarcinoma of the lung are negative. The antibody may be used for differentiating the types of lung tumours. N-CAM is an antigen, that is characteristic of cells of neuroectodermal origin. In the blood it is mainly found on NK-cells (CD56). It is a heavily glycosylated trans-membrane protein. On the 3. International Workshop for Lung tumours and Differentiation antigens (Zürich 1993) N-CAM was assigned to cluster 1 antigens of lung carcinoma (typical for SCLC). Extracellular domain of the N-CAM molecule (200, 100 and 25-27 kDa proteins of NCI-H82 SCLC cell line in western blot).

1. Broers V.J.L., Mijnheere E.P., Rot M.K., Schaart G. Sijlmans A., Boerman O.C., and Raaemaekers F.C.S. (1991) Novel antigens charakteristic of neuroendocrine malignancies. Cancer 67,3; 619-633. 2. Boerman O.C., Mijnheere E.P., Broers J.L.V., Vooijs G.P., and Ramaekers F.C.S. (1991) Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts. Int. J. Cancer 48; 457-462. 3. Stahel R.A., Gilks W.R., Schenker Th., and Gerardy-Schahn R. (1995) NK3.1 Third International Workshop on Lung Tumour and Differentiation Antigens: summary and report on NCAM studies. In: Leucocyte Typing V. Schlossman S.F. et al. eds. Oxford University Press, Oxford, N.Y. Tokyo.

Small volumes of anti-N-CAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS397288 is an antibody targeting N-CAM. Also known as N-CAM, Neuronal Cell Adhesion Molecule, CD56. Reactive in Human. Host: Mouse.