Pentosidine Antibody – Mouse

This antibody is suitable for the detection of bound and free pentosidine in tissues and tissue extracts. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) beta2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients with Alzheimer's disease. Pentosidine is one of the Maillard products, which were detected by Sell and Monnier (1989). Pentosidines have been shown to cross-link Arginine and Lysine residues. They were found in beta2-microglobulin of patients suffering from hemodialysis-related amyloidosis (Miyata et al., 1996). Reacts with pentosidine-HSA and free pentosidine in competitive ELISA.

1. Horiuchi S., Araki N., and Morino Y. (1991) Immunological approach to characterize advanced glycation end products of the Maillard reaction: Evidence for the presence of a common stucture. J. Biol. Chem. 266; 7329-7332. 2. Sell D.R. and Monnier V.M.(1989): Structure Elucidation of a Senescence Cross-link from Human Extracellular Matrix. Implication of pentoses in aging process. J.Biol.Chem.264: 21597-21602. 3. Miyata T, Taneda S., Kawai R., Ueda Y., Horiuchi S., Hara M., Maeda K., and Monnier V.M. (1996): Identification of pentosidine as a native structure for advanced glycation end products in ?2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. Proc.Natl.Acad.Sci.USA 93: 2353-2358.

Small volumes of anti-Pentosidine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS397309 is an antibody targeting Pentosidine. Also known as Pentosidine (Advanced Glycation End Product). Host: Mouse.