COVID 19 Spike 1 Receptor-Binding Domain (S1RBD) Coronavirus (COVID-19) Active Protein

Recombinant SARS-CoV-2 Spike Protein (RBD) consists of 234 amino acids (Arg319-Phe541) with C-terminal His-tag. It has an apparent molecular mass of ~25 kDa in SDS-PAGE. The concentration of protein was determined by BCA.

The SARS-CoV-2 glycosylated spike (S) protein highly exposed on the viral surface is a major determinant for virus binding and invasion into hose cells, which is a main target for neutralization antibody. The receptor-binding domain (RBD) in SARS-CoV-2 S protein is responsible for binding to human and bat angiotensin-converting enzyme 2 (ACE2) receptors.

Shajahan A, et al. (2020) Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2. bioRxiv, https://doi.org/10.1101/2020.04.01.020966.

Small volumes of COVID-19 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS398012 is an active protein targeting COVID-19. Also known as Receptor-Binding Domain (S1RBD). Host: HEK293.