Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1) ELISA Kit for Cavy

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.

Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: early endosome; cytosol; endosome

Molecular Function: Rap guanyl-nucleotide exchange factor activity; protein binding; SH3 domain binding

Biological Process: blood vessel development; cell-cell adhesion; negative regulation of protein kinase B signaling cascade; activation of MAPKK activity; nerve growth factor receptor signaling pathway; negative regulation of Ras protein signal transduction; platelet-derived growth factor receptor signaling pathway; signal transduction; Rap protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway