Irisin Recombinant Protein

Exercise enhances muscular endurance and strength, calories expenditure, and prevents the development of obesity and type 2 diabetes. These effects of exercise cannot be explained solely by the expenditure of calories in muscle. A recent study indicated that a novel hormone, irisin, plays an important role in the increase of total body energy expenditure by exercising muscle. Irisin is a cleaved and secreted fragment of a membrane protein FNDC5. And its circulating concentrations are increased after regular physical activity. Exercise induces the transcriptional regulator PGC-1alpha in the skeletal myocyte, which in turn drives the production of the FNDC5. Animal experiments suggested that irisin, cleaved form FNDC5, activates thermogenic programs in white adipose tissue (“browning"), including mitochondrial biogenesis and the expression of uncoupling protein 1 (UCP1), leading to mitochondrial heat production and energy expenditure. Irisin is highly conserved across species, and exercise also increases circulating irisin concentrations in humans. Therefore, the role of irisin in humans may be that it links physical activity to energy metabolic homeostasis, including weight control.
The recombinant irisin is the extracellular domain of FNDC5 (Asp16 to Thr136). Total 149 AA. Mw: 17 kDa (calculated). N-terminal His-tag and TEV cleavage site, 28 extraAA.

1. Irisin as a muscle-derived hormone stimulating thermogenesis - A critical update. Hofmann T, Elbelt U, Stengel A. Peptides. 2014 26;54C:89-100
2. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Pedersen BK, Febbraio MA. Nat Rev Endocrinol. 2012 8(8):457-65

Small volumes of Irisin recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS398078 is a recombinant protein targeting Irisin. Also known as Irisin: Human, His-tagged (Recombinant protein). Host: E Coli.