Major Urinary Protein 1 (Mup1) (MUP-1) Recombinant Protein

Major urinary protein 1 (Mup1), also known as Mup7, Up-1, Ltn-1, Mup-1, Mup-a, Mup10 and Lvtn-1, is a low molecular weight secreted protein produced predominantly from the liver. Structurally it belongs to the lipocalin family, which carries small hydrophobic ligands such as pheromones. It has been demonstrated that Mup1 is an important player in regulating energy expenditure and metabolism in mice. In both dietary and genetic obese mice, the circulating concentrations of Mup1 were markedly decreased compared with the lean controls. Replenishment of recombinant MUP-1 led to improved glucose tolerance and insulin sensitivity, as well as increased energy expenditure and locomotor activity in db/db diabetic mice. It was suggested that Mup1 also regulates systemic glucose and/or lipid metabolism through the paracrine/autocrine regulation of the hepatic gluconeogenic and/or lipogenic programs, respectively.
Total 190 AA. Mw: 22 KDa (calculated). N-terminal His-tag and TEV cleavage site, 28 extra AA.

1. Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. Hui X, et al J Biol Chem. 2009 May 22;284(21):14050-7.

Small volumes of MUP-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS398086 is a recombinant protein targeting MUP-1. Also known as Major urinary protein 1 (Mup1): Mouse (Recombinant protein). Host: E Coli.