Human IL22 Active Protein – Cat# MBS400105

Interleukin 22 Receptor Antagonist (IL22) Human Active Protein

Name: IL22 Active Protein; Interleukin 22 Receptor Antagonist; Human; MyBioSource
Brand: MyBioSource
SKU: MBS400105
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS400105

IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

interleukin 22 receptor antagonist (IL22), Active Protein

Full Product Name

Human interleukin 22 receptor antagonist (Y51A)

Product Gene Name

IL22 active protein

Product Synonym Names

Human Interleukin 22 (mIL-22) antagonist (Y51A)

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Il e-Ser-Ser.

Host

E Coli

Form/Format

White powder

Purity/Purification

Greater than 98.0% as determined by:
(a) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
(b) Gel filtration chromatography under non-denaturing conditions.

Preparation and Storage

Lyophilized IL-22 Y51A although stable at 4 degree C, should be stored desiccated below -18 degree C. Upon reconstitution interleukin-22 Y51A should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze-thaw cycles.

Molecular Weight

20,011 Da

OMIM

605330

3D Structure

ModBase 3D Structure for Q9GZX6

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IL-22 Y51A in sterile H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions containing carrier protein such as BSA, HSA or similar.

Protein Content

Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.18 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the DNAman computer analysis program of protein sequences.

Dimers and Aggregates

Less than 2% as determined by gel filtration under non-denaturing conditions.

Endotoxin

Less than 0.05 ng/ug (0.5 EU/ug) of recombinant IL-22 (Y51A).

Formulation

Interleukin-22 Y51A is lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3.

Biological Activity

human IL-22 Y51A mutant is capable of full inhibition of STAT3 phosphorylation induced by mouse interleukin 22 in HepG cells. Its affinity toward immobilized mIL-22 receptor alpha1 extracellular domain (mIL-22 Ralpha1-ECD) or IL-22 binding protein is similar to the non mutated mouse interleukin 22. Human IL-22 antagonist (Y51A) has no agonistic activity in this bioassay.

Product Categories/Family for IL22 active protein

Hormones; Cytokines and Growth Factors

Other Notes

Small volumes of IL22 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22 purchase

MBS400105 is an active protein targeting IL22. Also known as Human interleukin 22 receptor antagonist (Y51A). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22. It may not necessarily be applicable to this product.

NCBI GI #

10719562

NCBI GeneID

50616

NCBI Accession #

AAG22064.1

UniProt Primary Accession #

Q9GZX6

UniProt Related Accession #

Q9GZX6

NCBI Official Full Name

interleukin 22

NCBI Official Synonym Full Names

interleukin 22

NCBI Official Symbol

IL22

NCBI Official Synonym Symbols

TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23

UniProt Protein Name

Interleukin-22

UniProt Synonym Protein Names

Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF

Protein Family

Interleukin

UniProt Gene Name

IL22

UniProt Synonym Gene Names

ILTIF; ZCYTO18; IL-22; IL-TIF

UniProt Entry Name

IL22_HUMAN

NCBI Protein Information

interleukin-22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; cytokine Zcyto18

UniProt Comments for IL22

IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-22 receptor binding; cytokine activity

Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response

Research Articles on IL22

1. The IL-22 rs1179251 polymorphism was significantly associated with an increased risk of GC (p < 0.05).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL22 active protein

Reference Product	PubMed Publications
IL17A active protein	>34 publications with IL22 and IL17A
STAT3 active protein	>13 publications with IL22 and STAT3
IL22RA1 active protein	>5 publications with IL22 and IL22RA1
IL10RA active protein	>3 publications with IL22 and IL10RA
IL10RB active protein	>3 publications with IL22 and IL10RB
IL22RA2 active protein	>3 publications with IL22 and IL22RA2
STAT1 active protein	>2 publications with IL22 and STAT1
STAT5A active protein	>1 publications with IL22 and STAT5A

Pathways associated with IL22 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL22 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>29 publications with IL22 and Inflammation
Colitis Antibodies	>8 publications with IL22 and Colitis
Lung Diseases Antibodies	>7 publications with IL22 and Lung Diseases
Death Antibodies	>6 publications with IL22 and Death
Necrosis Antibodies	>4 publications with IL22 and Necrosis
Dermatitis Antibodies	>4 publications with IL22 and Dermatitis
Weight Loss Antibodies	>2 publications with IL22 and Weight Loss
Hypersensitivity Antibodies	>2 publications with IL22 and Hypersensitivity
Liver Diseases Antibodies	>2 publications with IL22 and Liver Diseases
Fibrosis Antibodies	>1 publications with IL22 and Fibrosis

Organs/Tissues associated with IL22 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>60 publications with IL22 and Blood