1 Integrase (HIV) Antibody – Rabbit Polyclonal

Human immunodeficiency virus type 1 (HIV-1), like all retroviruses, depends upon the integration of a DNA copy of its viral genome into host cell chromosomes as part of its infection cycle. This integration process is catalyzed by HIV-1 integrase, and the integration of HIV-1 DNA into the host chromosome is achieved by the integrase protein performing a series of DNA cleaving and ligation reactions.

HIV integrase is a multidomain, 31 kDa enzyme produced from the C-terminal portion of the HIV Pol gene product. The enzyme consists of three domains: an N-terminal HH-CC zinc finger domain believed to be partially responsible for multimerization, a central catalytic domain and a C-terminal DNA binding domain. Integrase is responsible for the integration of proviral DNA into the host genome, which is essential for HIV replication. Therefore, integrase remains an important antiviral target for new anti-HIV therapeutics.

Small volumes of anti-HIV-1 Integrase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS412230 is an antibody targeting HIV-1 Integrase. Also known as HIV-1 Integrase Antibody (Rabbit, Polyclonal). Host: Rabbit.