14-3-3-eta Antibody – Mouse Monoclonal

Monoclonal

IgG1

Mouse

Liquid

Affinity purified

100ug/100ul (lot specific)

Human, mouse and rat.

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

28,219 Da

Chromosome: 22; NC_000022.10 (32340479..32353590). Location: 22q12.3

113508

ModBase 3D Structure for Q04917

The 14.3.3 family of proteins were originally discovered as prominent protein spots on 2 dimensional gels. They are a family of 28-33kDa proteins which are often major proteins of the cytoplasm (1). They function as binding partners for phosphoserine and phosphthreonine sites in other proteins, though they have other binding partners which are not dependent on phosphorylation. These binding interactions are important in the regulation of molecules such as the signaling kinases in the MAP kinase pathway c-Raf and b-Raf, the proapoptotic molecules Bad and Bax and the cell cycle regulator Cdc25. There are 7 mammalian 14.3.3 proteins and they are normally expressed as homo or in some cases heterodimers. 14.3.3η or 14.3.3 eta is widely expressed and concentrated in the nervous system. The HGNC name for 14.3.3 is YWHAH, and an alternate name is tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 1, obviously due to a role for this protein in activation of tyrosine and tryptophan hydroxylases. One result of this is that the HGNC name is YWHAH. The 14.3.3η protein accumulates in the CSF of patients suffering form Creutzfeld Jacob Disease, and can be used for the this disease (2). Furthermore, this protein binds alphasynuclein in the Lewy bodies of Parkinson's disease and has been linked to early-onset schizopherenia (3,4). The HGNC name for this protein is YWHAH.

PBS, pH 7.4 with 0.02% sodium azide.