Mouse Anti-TACSTD2/TROP-2 Monoclonal Antibody – Cat# MBS415353

TACSTD2/TROP-2 Antibody – Mouse Monoclonal

Name: TACSTD2/TROP-2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS415353
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415353

Tumor-associated calcium signal transducer 2, a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts… More details

$455 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TACSTD2/TROP-2, Monoclonal Antibody

Full Product Name

Anti-human TACSTD2/TROP-2 Monoclonal Antibody

Product Gene Name

anti-TACSTD2/TROP-2 antibody

Product Synonym Names

Anti-human TACSTD2/TROP-2 Monoclonal

Clonality

Monoclonal

Isotype

IgG1 (Igh-4a allotype)

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Specificity

The antibody defines TROP-2 that is expressed on trophoblasts and choriocarcinoma cells but not on blood cells or other tumor cells.

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

35,709 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (59041095..59043166, complement). Location: 1p32

OMIM

137290

3D Structure

ModBase 3D Structure for P09758

Immunogen

Human choriocarcinoma cell line BeWo

Antibody Type

Primary Antibody

Storage Buffer

PBS, pH 7.4 with 0.02% sodium azide.

Applications Tested/Suitable for anti-TACSTD2/TROP-2 antibody

Immunofluorescence (IF), Immunocytochemistry (ICC)

Application Notes for anti-TACSTD2/TROP-2 antibody

Immunostaining, immunofluorescence: optimal dilutions to be determined by researchers.

Product References and Citations for anti-TACSTD2/TROP-2 antibody

Lipinski M, et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 78: 5147-5150, 1981.

Other Notes

Small volumes of anti-TACSTD2/TROP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TACSTD2/TROP-2 purchase

MBS415353 is an antibody targeting TACSTD2/TROP-2. Also known as Anti-human TACSTD2/TROP-2 Monoclonal Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TACSTD2/TROP-2. It may not necessarily be applicable to this product.

NCBI GI #

166795235

NCBI GeneID

4070

NCBI Accession #

NP_002344.2

UniProt Primary Accession #

P09758

UniProt Secondary Accession #

Q15658; Q6FG48; Q7Z7Q4; Q96QD2

UniProt Related Accession #

P09758

GenBank Nucleotide #

NM_002353.2

NCBI Official Full Name

Homo sapiens tumor-associated calcium signal transducer 2 (TACSTD2), mRNA

NCBI Official Synonym Full Names

tumor-associated calcium signal transducer 2

NCBI Official Symbol

TACSTD2

NCBI Official Synonym Symbols

EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1

UniProt Protein Name

Tumor-associated calcium signal transducer 2

UniProt Synonym Protein Names

Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1

UniProt Gene Name

TACSTD2

UniProt Synonym Gene Names

GA733-1; M1S1; TROP2

UniProt Entry Name

TACD2_HUMAN

NCBI Protein Information

tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733

NCBI Summary for TACSTD2/TROP-2

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

UniProt Comments for TACSTD2/TROP-2

Function: May function as a growth factor receptor.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Placenta, pancreatic carcinoma cell lines.

Post-translational modification: The N-terminus is blocked.

Involvement in disease: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain.

Research Articles on TACSTD2/TROP-2

1. show that Trop-2 enhances directional prostate cancer cell migration, through modulation of Rac1 GTPase activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TACSTD2/TROP-2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>46 publications with TACSTD2/TROP-2 and Neoplasms
Adenocarcinoma Antibodies	>11 publications with TACSTD2/TROP-2 and Adenocarcinoma
Prostatic Diseases Antibodies	>8 publications with TACSTD2/TROP-2 and Prostatic Diseases
Prostatic Neoplasms Antibodies	>8 publications with TACSTD2/TROP-2 and Prostatic Neoplasms
Neoplasms, Experimental Antibodies	>7 publications with TACSTD2/TROP-2 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>6 publications with TACSTD2/TROP-2 and Breast Neoplasms
Ovarian Diseases Antibodies	>5 publications with TACSTD2/TROP-2 and Ovarian Diseases
Ovarian Neoplasms Antibodies	>5 publications with TACSTD2/TROP-2 and Ovarian Neoplasms
Lung Neoplasms Antibodies	>4 publications with TACSTD2/TROP-2 and Lung Neoplasms
Lung Diseases Antibodies	>4 publications with TACSTD2/TROP-2 and Lung Diseases

Organs/Tissues associated with anti-TACSTD2/TROP-2 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>15 publications with TACSTD2/TROP-2 and Eye
Prostate Antibodies	>10 publications with TACSTD2/TROP-2 and Prostate
Liver Antibodies	>7 publications with TACSTD2/TROP-2 and Liver
Lymph Node Antibodies	>6 publications with TACSTD2/TROP-2 and Lymph Node
Lung Antibodies	>5 publications with TACSTD2/TROP-2 and Lung
Skin Antibodies	>2 publications with TACSTD2/TROP-2 and Skin
Uterus Antibodies	>2 publications with TACSTD2/TROP-2 and Uterus
Bone Antibodies	>2 publications with TACSTD2/TROP-2 and Bone
Bone Marrow Antibodies	>1 publications with TACSTD2/TROP-2 and Bone Marrow
Intestine Antibodies	>1 publications with TACSTD2/TROP-2 and Intestine