Mouse Anti-NCC27 Monoclonal Antibody – Cat# MBS415365

NCC27 Antibody – Mouse Monoclonal

Name: NCC27 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS415365
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415365

MBS415365 is an antibody targeting NCC27. Host: Mouse. More details

$540 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NCC27, Monoclonal Antibody

Full Product Name

Anti-NCC27 Antibody

Product Gene Name

anti-NCC27 antibody

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Specificity

Anti-NCC27 recognizes recombinant protein NCC27

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

26,923 Da

OMIM

602872

Raised In

Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein NCC27 as immunogen.

Storage Buffer

citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

Immunogen

Recombinant protein corresponding to full length NCC27

Applications Tested/Suitable for anti-NCC27 antibody

ELISA (EIA), Western Blot (WB-Re)

Application Notes for anti-NCC27 antibody

WB: 1:1000 analysis of recombinant protein NCC27 with Anti-NCC27

Product References and Citations for anti-NCC27 antibody

None

Other Notes

Small volumes of anti-NCC27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NCC27. It may not necessarily be applicable to this product.

NCBI GI #

48375182

NCBI GeneID

1192

NCBI Accession #

NP_001279.2

UniProt Secondary Accession #

Q15089; Q502X1

UniProt Related Accession #

O00299

GenBank Nucleotide #

NM_001288.4

NCBI Official Full Name

Homo sapiens chloride intracellular channel 1 (CLIC1), transcript variant 2, mRNA

NCBI Official Synonym Full Names

chloride intracellular channel 1

NCBI Official Symbol

CLIC1

NCBI Official Synonym Symbols

G6; NCC27

UniProt Protein Name

Chloride intracellular channel protein 1

UniProt Synonym Protein Names

Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC

UniProt Gene Name

CLIC1

UniProt Entry Name

CLIC1_HUMAN

NCBI Protein Information

chloride intracellular channel protein 1; RNCC protein; chloride channel ABP; hRNCC; nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein

NCBI Summary for NCC27

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

UniProt Comments for NCC27

CLIC1: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family.

Protein type: Membrane protein, integral; Channel, chloride

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; nuclear membrane; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nuclear envelope; nucleus; brush border; vesicle

Molecular Function: protein binding; chloride channel activity; voltage-gated ion channel activity

Biological Process: positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of cell cycle; chloride transport; signal transduction

Research Articles on NCC27

1. Mutation of the two charged amino acids (K37 and R29) in the putative transmembrane region of CLIC1 alters the biophysical properties of the ion channel in both artificial bilayers and cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-NCC27 antibody

Disease Name	Pubmed Publications
Liver Neoplasms Antibodies	>8 publications with NCC27 and Liver Neoplasms
Nervous System Diseases Antibodies	>8 publications with NCC27 and Nervous System Diseases
Liver Diseases Antibodies	>8 publications with NCC27 and Liver Diseases
Brain Diseases Antibodies	>7 publications with NCC27 and Brain Diseases
Neoplasm Metastasis Antibodies	>7 publications with NCC27 and Neoplasm Metastasis
Carcinoma, Hepatocellular Antibodies	>6 publications with NCC27 and Carcinoma, Hepatocellular
Neoplasms, Experimental Antibodies	>5 publications with NCC27 and Neoplasms, Experimental
Necrosis Antibodies	>5 publications with NCC27 and Necrosis
Inflammation Antibodies	>4 publications with NCC27 and Inflammation
Vascular Diseases Antibodies	>2 publications with NCC27 and Vascular Diseases

Organs/Tissues associated with anti-NCC27 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with NCC27 and Blood
Brain Antibodies	>9 publications with NCC27 and Brain
Liver Antibodies	>8 publications with NCC27 and Liver
Muscle Antibodies	>6 publications with NCC27 and Muscle
Bone Antibodies	>6 publications with NCC27 and Bone
Kidney Antibodies	>6 publications with NCC27 and Kidney
Stomach Antibodies	>4 publications with NCC27 and Stomach
Lymph Antibodies	>3 publications with NCC27 and Lymph
Vascular Antibodies	>3 publications with NCC27 and Vascular
Lymph Node Antibodies	>3 publications with NCC27 and Lymph Node