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MCL1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415391

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively… More details

$410 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MCL1, Monoclonal Antibody
Full Product Name
Anti-MCL1 Antibody
Product Gene Name
anti-MCL1 antibody
Clonality
Monoclonal
Isotype
IgG
Clone Number
MCL.C9
Host
Mouse
Form/Format
Liquid
Concentration
100ug/100ul (lot specific)
Specificity
Recognize human MCL1 protein. Other species not tested.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
28,662 Da
OMIM
159552
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Immunogen
Recombinant human MCL1 protein.
Applications Tested/Suitable for anti-MCL1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MCL1 antibody
Western blot (1:1000) and ELISA (1:2000~5000). Mcl-1 is an anti-apoptotic member of Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl-1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl-2 family members, and inhibits apoptosis by a number of cytotoxic stimuli.

Western Blot (WB) of anti-MCL1 antibody

Mouse Anti-MCL1 Monoclonal Antibody – Cat# MBS415391

Other Notes

Small volumes of anti-MCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCL1 purchase

MBS415391 is an antibody targeting MCL1. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MCL1. It may not necessarily be applicable to this product.

NCBI GI #
4235637
NCBI GeneID
4170
NCBI Accession #
AAD13299.1
UniProt Secondary Accession #
Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04
UniProt Related Accession #
Q07820
NCBI Official Full Name
myeloid cell leukemia sequence 1
NCBI Official Synonym Full Names
myeloid cell leukemia 1
NCBI Official Symbol
MCL1
NCBI Official Synonym Symbols
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
UniProt Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Synonym Protein Names
Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
Protein Family
Induced myeloid leukemia cell differentiation protein
UniProt Gene Name
MCL1
UniProt Entry Name
MCL1_HUMAN
NCBI Protein Information
induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related)

UniProt Comments for MCL1

MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Apoptosis; Membrane protein, integral; Channel, misc.; Inhibitor; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding

Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; multicellular organismal development; cellular homeostasis; cell fate determination
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Research Articles on MCL1

1. Clitocine may activate Bak by disrupting the interaction between Mcl-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MCL1 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-MCL1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >60 publications with MCL1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >56 publications with MCL1 and Lung Neoplasms
 Necrosis Antibodies  >50 publications with MCL1 and Necrosis
 Breast Neoplasms Antibodies  >42 publications with MCL1 and Breast Neoplasms
 Liver Diseases Antibodies  >39 publications with MCL1 and Liver Diseases
 Liver Neoplasms Antibodies  >32 publications with MCL1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >32 publications with MCL1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >30 publications with MCL1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >28 publications with MCL1 and Inflammation
 Multiple Myeloma Antibodies  >28 publications with MCL1 and Multiple Myeloma

Organs/Tissues associated with anti-MCL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >151 publications with MCL1 and Blood
 Lung Antibodies  >79 publications with MCL1 and Lung
 Liver Antibodies  >71 publications with MCL1 and Liver
 Bone Antibodies  >61 publications with MCL1 and Bone
 Bone Marrow Antibodies  >45 publications with MCL1 and Bone Marrow
 Brain Antibodies  >39 publications with MCL1 and Brain
 Prostate Antibodies  >31 publications with MCL1 and Prostate
 Vascular Antibodies  >22 publications with MCL1 and Vascular
 Skin Antibodies  >19 publications with MCL1 and Skin
 Lymph Node Antibodies  >16 publications with MCL1 and Lymph Node
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