IPO4 Antibody – Rabbit Polyclonal

IPO4: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Karyopherin

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: protein complex; membrane; cytoplasm; nuclear chromatin; nuclear pore

Molecular Function: protein binding; Ran GTPase binding

Biological Process: intracellular protein transport; protein transport; DNA replication-independent nucleosome assembly; DNA replication-dependent nucleosome assembly