PPP2CA Antibody – Rabbit Polyclonal

PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; mitochondrion; membrane; plasma membrane; cytosol; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein dimerization activity; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity

Biological Process: regulation of cell adhesion; second-messenger-mediated signaling; mitotic nuclear envelope reassembly; fibroblast growth factor receptor signaling pathway; apoptosis; RNA splicing; regulation of protein amino acid autophosphorylation; regulation of Wnt receptor signaling pathway; protein amino acid dephosphorylation; response to organic substance; meiotic cell cycle; regulation of transcription, DNA-dependent; regulation of cell differentiation; regulation of growth; mRNA catabolic process, nonsense-mediated decay; negative regulation of tyrosine phosphorylation of Stat3 protein; mesoderm development; gene expression; regulation of protein catabolic process; regulation of receptor activity; negative regulation of cell growth; mitotic cell cycle; ceramide metabolic process; regulation of DNA replication; inactivation of MAPK activity