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WEE1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415512

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA… More details

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Product Overview

Product Name
WEE1, Polyclonal Antibody
Full Product Name
Anti-WEE1 Antibody
Product Gene Name
anti-WEE1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
49,072 Da
OMIM
193525
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Synthetic peptide conjugated to KLH
Applications Tested/Suitable for anti-WEE1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-WEE1 antibody
Peptide ELISA titer: 1:80,000
Western blot analysis: 1:200-500
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-WEE1 antibody

Rabbit Anti-WEE1 Polyclonal Antibody – Cat# MBS415512

Product References and Citations for anti-WEE1 antibody

(1) Igarashi,M., Nagata,A., Jinno,S., Suto,K. and Okayama,H. Wee1(+)-like gene in human cells.Nature 1991;353 (6339): 80-83.

Other Notes

Small volumes of anti-WEE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WEE1 purchase

MBS415512 is an antibody targeting WEE1. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WEE1. It may not necessarily be applicable to this product.

NCBI GI #
221307497
NCBI GeneID
7465
NCBI Accession #
NP_003381.1
UniProt Secondary Accession #
B3KVE1; D3DQV0
UniProt Related Accession #
P30291
GenBank Nucleotide #
NM_003390
NCBI Official Full Name
Homo sapiens WEE1 G2 checkpoint kinase (WEE1), transcript variant 1, mRNA
NCBI Official Synonym Full Names
WEE1 G2 checkpoint kinase
NCBI Official Symbol
WEE1
NCBI Official Synonym Symbols
WEE1A; WEE1hu
UniProt Protein Name
Wee1-like protein kinase
UniProt Synonym Protein Names
Wee1A kinase
Protein Family
Mitosis inhibitor protein kinase
UniProt Gene Name
WEE1
UniProt Entry Name
WEE1_HUMAN
NCBI Protein Information
wee1-like protein kinase; WEE1 homolog; wee1A kinase

UniProt Comments for WEE1

Wee1: a protein kinase of the WEE family. A nuclear protein which catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.10.2; Other group; WEE family

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding

Biological Process: mitosis; peptidyl-tyrosine phosphorylation; cell division; establishment of cell polarity; regulation of cell cycle; mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; G2/M transition of mitotic cell cycle; blood coagulation; neurite morphogenesis; G1/S transition of mitotic cell cycle
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Research Articles on WEE1

1. These results suggest that specific inhibition of Wee1 has deleterious effects on the proliferation and survival of p53 inactive tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WEE1 antibody

 Reference Product  PubMed Publications
 CDK1 antibody  >159 publications with WEE1 and CDK1
 CDC25A antibody  >136 publications with WEE1 and CDC25A
 CCNB1 antibody  >83 publications with WEE1 and CCNB1
 CDC25C antibody  >68 publications with WEE1 and CDC25C
 CDK2 antibody  >45 publications with WEE1 and CDK2
 PLK1 antibody  >25 publications with WEE1 and PLK1
 CDC25B antibody  >17 publications with WEE1 and CDC25B
 CHEK1 antibody  >4 publications with WEE1 and CHEK1
 CDCA3 antibody  >3 publications with WEE1 and CDCA3
 CABLES1 antibody  >2 publications with WEE1 and CABLES1

Pathways associated with anti-WEE1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle - G2/M Transition Pathway antibodies  Cell Cycle - G2/M Transition Pathway Diagram
 Cell Cycle - G2/M Transition Pathway antibodies  Cell Cycle - G2/M Transition Pathway Diagram
 Chk1/Chk2(Cds1) Mediated Inactivation Of Cyclin B:Cdk1 Complex Pathway antibodies  Chk1/Chk2(Cds1) Mediated Inactivation Of Cyclin B:Cdk1 Complex Pathway Diagram
 Cyclin A/B1 Associated Events During G2/M Transition Pathway antibodies  Cyclin A/B1 Associated Events During G2/M Transition Pathway Diagram

Diseases associated with anti-WEE1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >23 publications with WEE1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >15 publications with WEE1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >14 publications with WEE1 and Liver Diseases
 Brain Diseases Antibodies  >12 publications with WEE1 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >12 publications with WEE1 and Carcinoma, Squamous Cell
 Liver Neoplasms Antibodies  >10 publications with WEE1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >8 publications with WEE1 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >7 publications with WEE1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >7 publications with WEE1 and Lung Neoplasms
 Kidney Diseases Antibodies  >5 publications with WEE1 and Kidney Diseases

Organs/Tissues associated with anti-WEE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >24 publications with WEE1 and Liver
 Brain Antibodies  >23 publications with WEE1 and Brain
 Blood Antibodies  >22 publications with WEE1 and Blood
 Kidney Antibodies  >14 publications with WEE1 and Kidney
 Lung Antibodies  >13 publications with WEE1 and Lung
 Prostate Antibodies  >13 publications with WEE1 and Prostate
 Bone Antibodies  >11 publications with WEE1 and Bone
 Ovary Antibodies  >9 publications with WEE1 and Ovary
 Embryonic Tissue Antibodies  >8 publications with WEE1 and Embryonic Tissue
 Vascular Antibodies  >8 publications with WEE1 and Vascular
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