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CUL5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415579

MBS415579 is an antibody targeting CUL5. Reactive in Human, Mouse, Rat. Not yet tested in other species.. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CUL5, Polyclonal Antibody
Full Product Name
Anti-CUL5 Antibody
Product Gene Name
anti-CUL5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat. Not yet tested in other species.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
90,955 Da
OMIM
601741
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal CUL5 antibody was raised against a peptide from a peptide from near the C terminal residues of human CUL5 protein.
Applications Tested/Suitable for anti-CUL5 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CUL5 antibody
Peptide ELISA titer: 1:40,000-1:80,000
Immunohistochemistry: 1:50-500
Optimal dilutions/concentrations should be determined by the end user

Immunohistochemistry (IHC) of anti-CUL5 antibody

Rabbit Anti-CUL5 Polyclonal Antibody – Cat# MBS415579

Product References and Citations for anti-CUL5 antibody

(1) An,P., Duggal,P., Wang,L.H., O'Brien,S.J., et al.Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.PLoS Genet. 3 (1), E19 (2007)

Other Notes

Small volumes of anti-CUL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CUL5. It may not necessarily be applicable to this product.

NCBI GI #
40254446
NCBI GeneID
8065
NCBI Accession #
NP_003469.2
UniProt Secondary Accession #
O14766; Q9BZC6; A8K960
UniProt Related Accession #
Q93034
GenBank Nucleotide #
NM_003478.3
NCBI Official Full Name
cullin-5
NCBI Official Synonym Full Names
cullin 5
NCBI Official Symbol
CUL5
NCBI Official Synonym Symbols
VACM1; VACM-1
UniProt Protein Name
Cullin-5
UniProt Synonym Protein Names
Vasopressin-activated calcium-mobilizing receptor 1; VACM-1
Protein Family
Cullin
UniProt Gene Name
CUL5
UniProt Entry Name
CUL5_HUMAN
NCBI Protein Information
cullin-5; CUL-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); Vasopressin-activated calcium-mobilizing receptor-1; vasopressin-activated calcium-mobilizing receptor 1

UniProt Comments for CUL5

CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: Cul5-RING ubiquitin ligase complex; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein heterodimerization activity; ubiquitin protein ligase binding; calcium channel activity; receptor activity

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; cell proliferation; cytosolic calcium ion homeostasis; viral reproduction; protein ubiquitination; response to osmotic stress; cell cycle arrest; G1/S transition of mitotic cell cycle
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Research Articles on CUL5

1. Data indicate that cell surface adhesion molecules VCAM-1 and P-selectin play some roles in mechanical stretch-induced HL-60 cell adhesion to mouse common carotid arteries.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CUL5 antibody

 Reference Product  PubMed Publications
 RBX1 antibody  >21 publications with CUL5 and RBX1
 NEDD8 antibody  >12 publications with CUL5 and NEDD8
 ASB2 antibody  >4 publications with CUL5 and ASB2
 ERBB2 antibody  >2 publications with CUL5 and ERBB2

Pathways associated with anti-CUL5 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-CUL5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with CUL5 and Inflammation
 Carcinoma Antibodies  >4 publications with CUL5 and Carcinoma
 Breast Neoplasms Antibodies  >4 publications with CUL5 and Breast Neoplasms
 Kidney Diseases Antibodies  >3 publications with CUL5 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with CUL5 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >2 publications with CUL5 and Adenocarcinoma
 Uterine Neoplasms Antibodies  >2 publications with CUL5 and Uterine Neoplasms
 Liver Diseases Antibodies  >1 publications with CUL5 and Liver Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with CUL5 and Uterine Cervical Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with CUL5 and Neoplasms, Experimental

Organs/Tissues associated with anti-CUL5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with CUL5 and Blood
 Brain Antibodies  >14 publications with CUL5 and Brain
 Vascular Antibodies  >13 publications with CUL5 and Vascular
 Kidney Antibodies  >10 publications with CUL5 and Kidney
 Liver Antibodies  >8 publications with CUL5 and Liver
 Lung Antibodies  >5 publications with CUL5 and Lung
 Heart Antibodies  >5 publications with CUL5 and Heart
 Muscle Antibodies  >4 publications with CUL5 and Muscle
 Nerve Antibodies  >3 publications with CUL5 and Nerve
 Embryonic Tissue Antibodies  >2 publications with CUL5 and Embryonic Tissue
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