Coronin 1a (CORO1A) Antibody – Rabbit Polyclonal

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

Function: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Ref.10

Subunit structure: Binds actin.

Subcellular location: Cytoplasm › cytoskeleton

By similarity. Cytoplasm › cell cortex

By similarity. Cytoplasmic vesicle › phagosome membrane

By similarity. Note: In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification

By similarity.

Tissue specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Post-translational modification: phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.

Sequence similarities: Belongs to the WD repeat coronin family.Contains 7 WD repeats.