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TLE4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415617

MBS415617 is an antibody targeting TLE4. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TLE4, Polyclonal Antibody
Full Product Name
Anti-TLE4 Antibody
Product Gene Name
anti-TLE4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
81,011 Da
OMIM
605132
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Peptide
Applications Tested/Suitable for anti-TLE4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TLE4 antibody
Optimal dilutions to be determined by researchers

Western Blot (WB) #2 of anti-TLE4 antibody

Rabbit Anti-TLE4 Polyclonal Antibody – Cat# MBS415617

Immunohistochemistry (IHC) of anti-TLE4 antibody

Rabbit Anti-TLE4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS415617

Other Notes

Small volumes of anti-TLE4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TLE4. It may not necessarily be applicable to this product.

NCBI GI #
34915994
NCBI GeneID
7091
NCBI Accession #
NP_008936.2
UniProt Secondary Accession #
Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9; F8W6T6
UniProt Related Accession #
Q04727
GenBank Nucleotide #
NM_007005.4
NCBI Official Full Name
transducin-like enhancer protein 4 isoform 3
NCBI Official Synonym Full Names
transducin-like enhancer of split 4
NCBI Official Symbol
TLE4
NCBI Official Synonym Symbols
ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI)
UniProt Protein Name
Transducin-like enhancer protein 4
UniProt Synonym Protein Names
Grg-4; Groucho-related protein 4
Protein Family
Transducin-like enhancer protein
UniProt Gene Name
TLE4
UniProt Entry Name
TLE4_HUMAN
NCBI Protein Information
transducin-like enhancer protein 4; B lymphocyte gene 1; enhancer of split groucho 4; groucho-related protein 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

UniProt Comments for TLE4

TLE4: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. In all tissues examined, mostly in brain, and muscle. Belongs to the WD repeat Groucho/TLE family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 9q21.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on TLE4

1. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TLE4 antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram

Diseases associated with anti-TLE4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with TLE4 and Carcinoma
 Disease Models, Animal Antibodies  >1 publications with TLE4 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with TLE4 and Neoplasms, Experimental
 Hypertrophy Antibodies  >1 publications with TLE4 and Hypertrophy
 Embryo Loss Antibodies  >1 publications with TLE4 and Embryo Loss
 Adenocarcinoma Antibodies  >1 publications with TLE4 and Adenocarcinoma
 Adenoma Antibodies  >1 publications with TLE4 and Adenoma
 Precancerous Conditions Antibodies  >1 publications with TLE4 and Precancerous Conditions
 Congenital Abnormalities Antibodies  >1 publications with TLE4 and Congenital Abnormalities
 Inflammation Antibodies  >1 publications with TLE4 and Inflammation

Organs/Tissues associated with anti-TLE4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with TLE4 and Brain
 Embryonic Tissue Antibodies  >8 publications with TLE4 and Embryonic Tissue
 Blood Antibodies  >5 publications with TLE4 and Blood
 Nerve Antibodies  >5 publications with TLE4 and Nerve
 Kidney Antibodies  >5 publications with TLE4 and Kidney
 Bone Antibodies  >4 publications with TLE4 and Bone
 Eye Antibodies  >3 publications with TLE4 and Eye
 Bone Marrow Antibodies  >2 publications with TLE4 and Bone Marrow
 Skin Antibodies  >2 publications with TLE4 and Skin
 Lung Antibodies  >2 publications with TLE4 and Lung
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