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ALKBH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415625

MBS415625 is an antibody targeting ALKBH1. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit. Rabbit Polyclonal Antibody More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ALKBH1, Polyclonal Antibody
Full Product Name
Anti-ALKBH1 Antibody
Product Gene Name
anti-ALKBH1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
43,832 Da
OMIM
605345
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Raised against a recombinate human ALKBH1 protein 8-216aa (BC025787)
Applications Tested/Suitable for anti-ALKBH1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALKBH1 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Testing Data of anti-ALKBH1 antibody

Rabbit Anti-ALKBH1 Polyclonal Antibody – Cat# MBS415625

Testing Data of anti-ALKBH1 antibody

Rabbit Anti-ALKBH1 Polyclonal Antibody, Testing Data – Cat# MBS415625

Product References and Citations for anti-ALKBH1 antibody

Muller,T.A., Meek,K. and Hausinger,R.P. Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites. DNA Repair (Amst.) 9 (1), 58-65 (2010)

Other Notes

Small volumes of anti-ALKBH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH1. It may not necessarily be applicable to this product.

NCBI GI #
19343599
NCBI GeneID
8846
NCBI Accession #
BC025787
UniProt Secondary Accession #
Q8TAU1; Q9ULA7
UniProt Related Accession #
Q13686
NCBI Official Full Name
Homo sapiens alkB, alkylation repair homolog 1 (E. coli), mRNA
NCBI Official Synonym Full Names
alkB, alkylation repair homolog 1 (E. coli)
NCBI Official Symbol
ALKBH1
NCBI Official Synonym Symbols
ABH; ABH1; alkB; hABH; ALKBH
UniProt Protein Name
Alkylated DNA repair protein alkB homolog 1
UniProt Synonym Protein Names
Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1 (EC:4.2.99.18); DNA oxidative demethylase ALKBH1
Protein Family
DNA demethylase
UniProt Gene Name
ALKBH1
UniProt Entry Name
ALKB1_HUMAN
NCBI Protein Information
alkylated DNA repair protein alkB homolog 1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenase ABH1

NCBI Summary for ALKBH1

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

UniProt Comments for ALKBH1

ALKBH: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. Belongs to the alkB family.

Protein type: DNA repair, damage; EC 1.14.11.33; EC 4.2.99.18

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: mitochondrion

Molecular Function: DNA-(apurinic or apyrimidinic site) lyase activity; ferrous iron binding; chemoattractant activity

Biological Process: developmental growth; DNA dealkylation; positive chemotaxis; in utero embryonic development; neuron migration; RNA repair; negative regulation of neuron apoptosis; DNA repair; DNA catabolic process, endonucleolytic; neurite development; placenta development
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Research Articles on ALKBH1

1. ALKBH1's role in class switch recombination and abasic site cleavage during base excision repair

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALKBH1 antibody

 Reference Product  PubMed Publications
 ALKBH3 antibody  >6 publications with ALKBH1 and ALKBH3
 FTO antibody  >5 publications with ALKBH1 and FTO
 ALKBH8 antibody  >4 publications with ALKBH1 and ALKBH8
 ALKBH2 antibody  >4 publications with ALKBH1 and ALKBH2
 ALKBH7 antibody  >2 publications with ALKBH1 and ALKBH7
 ALKBH4 antibody  >1 publications with ALKBH1 and ALKBH4

Pathways associated with anti-ALKBH1 antibody

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with anti-ALKBH1 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >1 publications with ALKBH1 and Neoplasms, Experimental
 Craniofacial Abnormalities Antibodies  >1 publications with ALKBH1 and Craniofacial Abnormalities

Organs/Tissues associated with anti-ALKBH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with ALKBH1 and Testis
 Lung Antibodies  >3 publications with ALKBH1 and Lung
 Bone Antibodies  >2 publications with ALKBH1 and Bone
 Placenta Antibodies  >1 publications with ALKBH1 and Placenta
 Eye Antibodies  >1 publications with ALKBH1 and Eye
 Blood Antibodies  >1 publications with ALKBH1 and Blood
 Connective Tissue Antibodies  >1 publications with ALKBH1 and Connective Tissue
 Skin Antibodies  >1 publications with ALKBH1 and Skin
 Embryonic Tissue Antibodies  >1 publications with ALKBH1 and Embryonic Tissue
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