ALDH1A2 Antibody – Rabbit Polyclonal

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

ALDH1A2: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.2.1.36; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; 3-chloroallyl aldehyde dehydrogenase activity; retinal binding; retinal dehydrogenase activity

Biological Process: retinoic acid receptor signaling pathway; heart morphogenesis; embryonic forelimb morphogenesis; neural tube development; retinal metabolic process; neural crest cell development; positive regulation of apoptosis; vitamin A metabolic process; response to estradiol stimulus; response to vitamin A; neuron differentiation; anterior/posterior pattern formation; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; retinol metabolic process; pancreas development; determination of bilateral symmetry; positive regulation of cell proliferation; retinoic acid metabolic process; kidney development; embryonic gut development; proximal/distal pattern formation; hindbrain development; cardiac muscle development; blood vessel development; regulation of endothelial cell proliferation; liver development; embryonic camera-type eye development; pituitary gland development; response to cytokine stimulus; 9-cis-retinoic acid biosynthetic process; midgut development; lung development