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CD59 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415704

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD59, Polyclonal Antibody
Full Product Name
Anti-CD59 Antibody
Product Gene Name
anti-CD59 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
14,177 Da
OMIM
107271
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal CD59 (1) antibody was raised against a recombinate human CD59 protein 29-102aa (BC001506).
Applications Tested/Suitable for anti-CD59 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CD59 antibody
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Testing Data of anti-CD59 antibody

Rabbit Anti-CD59 Polyclonal Antibody – Cat# MBS415704

Product References and Citations for anti-CD59 antibody

(1) Wickham,S.E., Hotze,E.M., Farrand,A.J. et al. Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J. Biol. Chem. 286 (23), 20952-20962 (2011).

Other Notes

Small volumes of anti-CD59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD59 purchase

MBS415704 is an antibody targeting CD59. Reactive in Human. Predicted: Mouse, Rat.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.

NCBI GI #
42716299
NCBI GeneID
966
NCBI Accession #
NP_976076.1
UniProt Related Accession #
P13987
GenBank Nucleotide #
NM_203331.2
NCBI Official Full Name
CD59 glycoprotein preproprotein
NCBI Official Synonym Full Names
CD59 molecule, complement regulatory protein
NCBI Official Symbol
CD59
NCBI Official Synonym Symbols
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
UniProt Protein Name
CD59 glycoprotein
UniProt Synonym Protein Names
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
Protein Family
CD59 glycoprotein
UniProt Gene Name
CD59
UniProt Entry Name
CD59_HUMAN
NCBI Protein Information
CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); Ly-6-like protein; MEM43 antigen; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; membrane inhibitor of reactive lysis; protectin; surface anitgen recognized by monoclonal antibody 16.3A5

UniProt Comments for CD59

CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; compact myelin; extracellular space; cell surface; focal adhesion; membrane; plasma membrane; extracellular region; sarcolemma; vesicle

Molecular Function: complement binding; protein binding

Biological Process: cell activation; cell surface receptor linked signal transduction; regulation of complement activation; innate immune response; negative regulation of activation of membrane attack complex; positive regulation of T cell proliferation; blood coagulation; negative regulation of apoptosis

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
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Research Articles on CD59

1. The presence of CD55- and/or CD59-deficient erythrocytic populations in patients with rheumatic diseases reflects an immune-mediated bone-marrow derived phenomenon.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD59 antibody

 Reference Product  PubMed Publications
 CD55 antibody  >826 publications with CD59 and CD55
 CD46 antibody  >317 publications with CD59 and CD46
 PIGA antibody  >24 publications with CD59 and PIGA
 CAV1 antibody  >5 publications with CD59 and CAV1
 C8A antibody  >1 publications with CD59 and C8A

Pathways associated with anti-CD59 antibody

 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram

Diseases associated with anti-CD59 antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >407 publications with CD59 and Anemia
 Inflammation Antibodies  >151 publications with CD59 and Inflammation
 Necrosis Antibodies  >79 publications with CD59 and Necrosis
 Nervous System Diseases Antibodies  >76 publications with CD59 and Nervous System Diseases
 Disease Models, Animal Antibodies  >75 publications with CD59 and Disease Models, Animal
 Kidney Diseases Antibodies  >53 publications with CD59 and Kidney Diseases
 Brain Diseases Antibodies  >35 publications with CD59 and Brain Diseases
 Lung Diseases Antibodies  >31 publications with CD59 and Lung Diseases
 CD59 Deficiency Antibodies  >28 publications with CD59 and CD59 Deficiency
 Breast Neoplasms Antibodies  >27 publications with CD59 and Breast Neoplasms

Organs/Tissues associated with anti-CD59 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >947 publications with CD59 and Blood
 Vascular Antibodies  >203 publications with CD59 and Vascular
 Bone Antibodies  >189 publications with CD59 and Bone
 Bone Marrow Antibodies  >181 publications with CD59 and Bone Marrow
 Kidney Antibodies  >121 publications with CD59 and Kidney
 Heart Antibodies  >92 publications with CD59 and Heart
 Muscle Antibodies  >76 publications with CD59 and Muscle
 Liver Antibodies  >75 publications with CD59 and Liver
 Lung Antibodies  >67 publications with CD59 and Lung
 Brain Antibodies  >63 publications with CD59 and Brain
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