HES-1 Antibody – Rabbit Polyclonal

HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 3q28-q29

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; chaperone binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; midbrain-hindbrain boundary morphogenesis; hindbrain morphogenesis; radial glial cell differentiation in the forebrain; somatic stem cell maintenance; regulation of fat cell differentiation; regulation of timing of neuron differentiation; cell maturation; positive regulation of JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; midbrain development; positive regulation of cell proliferation; adenohypophysis development; trochlear nerve development; positive regulation of T cell proliferation; protein complex assembly; oculomotor nerve development; cell adhesion; positive regulation of mitotic cell cycle, embryonic; positive regulation of Notch signaling pathway; positive regulation of BMP signaling pathway; positive regulation of astrocyte differentiation; STAT protein nuclear translocation; positive regulation of DNA binding; nervous system development; smoothened signaling pathway; Notch signaling pathway; cell migration; auditory receptor cell fate determination; thymus development; liver development; endocrine pancreas development; negative regulation of oligodendrocyte differentiation; telencephalon development; lateral inhibition; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; lung development