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CLTR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601480

Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CLTR1, Polyclonal Antibody
Full Product Name
CLTR1 Antibody
Product Gene Name
anti-CLTR1 antibody
Product Synonym Gene Name
CYSLTR1
Product Synonym Names
CLTR1_HUMAN; CYSLT 1; CysLT(1); CYSLT1R; CYSLTR 1; CYSLTR; CysLTR vide supra; CysLTR1; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; MGC46139
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CLTR1 antibody detects endogenous levels of total CLTR1
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
CLTR1 peptide (MBS9617012) is used for blocking the activity of CLTR1 antibody (MBS9601480)
Molecular Weight
Observed: 39 kDa
Predicted: 39 kDa
3D Structure
ModBase 3D Structure for Q9Y271
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human CLTR1
Subcellular Location
Cell Membrane
Tissue Specificity
Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Predicted Cross Reactivity
Rabbit
Similarity
Rabbit (82%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CLTR1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CLTR1 antibody
WB: 1:500-1:2000
IF: 1:100-1:500

Immunofluorescence (IF) of anti-CLTR1 antibody

MBS9601480 staining 293T  cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Rabbit Anti-CLTR1 Polyclonal Antibody – Cat# MBS9601480

Western Blot (WB) of anti-CLTR1 antibody

Western blot analysis of CLTR1 expression in COS7 cells
Rabbit Anti-CLTR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9601480

Other Notes

Small volumes of anti-CLTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLTR1 purchase

MBS9601480 is an antibody targeting CLTR1. Also known as CLTR1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLTR1. It may not necessarily be applicable to this product.

NCBI GI #
532164733
NCBI GeneID
10800
NCBI Accession #
NP_001269115.1
UniProt Primary Accession #
Q9Y271
UniProt Secondary Accession #
Q5JS94; Q8IV19; B2R954; D3DTE4
UniProt Related Accession #
Q9Y271
GenBank Nucleotide #
NM_001282186.1
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Symbol
CYSLTR1
NCBI Official Synonym Symbols
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
UniProt Gene Name
CYSLTR1
UniProt Synonym Gene Names
CYSLT1; CysLTR1; LTD4 receptor
NCBI Protein Information
cysteinyl leukotriene receptor 1

NCBI Summary for CLTR1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for CLTR1

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
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Research Articles on CLTR1

1. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLTR1 antibody

 Reference Product  PubMed Publications
 CYSLTR2 antibody  >20 publications with CLTR1 and CYSLTR2
 TBXA2R antibody  >5 publications with CLTR1 and TBXA2R
 GPR17 antibody  >3 publications with CLTR1 and GPR17
 LTB4R2 antibody  >1 publications with CLTR1 and LTB4R2

Pathways associated with anti-CLTR1 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with anti-CLTR1 antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >49 publications with CLTR1 and Asthma
 Lung Diseases, Obstructive Antibodies  >33 publications with CLTR1 and Lung Diseases, Obstructive
 Lung Diseases Antibodies  >33 publications with CLTR1 and Lung Diseases
 Inflammation Antibodies  >22 publications with CLTR1 and Inflammation
 Drug Hypersensitivity Antibodies  >11 publications with CLTR1 and Drug Hypersensitivity
 Drug-Related Side Effects and Adverse Reactions Antibodies  >8 publications with CLTR1 and Drug-Related Side Effects and Adverse Reactions
 Asthma, Aspirin-Induced Antibodies  >8 publications with CLTR1 and Asthma, Aspirin-Induced
 Necrosis Antibodies  >6 publications with CLTR1 and Necrosis
 Disease Models, Animal Antibodies  >4 publications with CLTR1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with CLTR1 and Cardiovascular Diseases

Organs/Tissues associated with anti-CLTR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with CLTR1 and Blood
 Tonsil Antibodies  >2 publications with CLTR1 and Tonsil
 Connective Tissue Antibodies  >1 publications with CLTR1 and Connective Tissue
 Lymph Node Antibodies  >1 publications with CLTR1 and Lymph Node
 Uterus Antibodies  >1 publications with CLTR1 and Uterus
 Trachea Antibodies  >1 publications with CLTR1 and Trachea
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