INPP5K Antibody – Rabbit Polyclonal

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

INPP5K: Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.56; Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: ruffle; neuron projection; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; trans-Golgi network; nucleus; cytosol

Molecular Function: protein binding; inositol trisphosphate phosphatase activity; inositol-polyphosphate 5-phosphatase activity; lipid phosphatase activity; inositol bisphosphate phosphatase activity; vasopressin receptor activity

Biological Process: negative regulation of MAP kinase activity; positive regulation of transcription, DNA-dependent; regulation of glycogen biosynthetic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of insulin receptor signaling pathway; glucose homeostasis; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; negative regulation of dephosphorylation; negative regulation of glycogen biosynthetic process; negative regulation of retroviral genome replication; negative regulation of calcium ion transport; negative regulation of protein kinase B signaling cascade; negative regulation of stress fiber formation; in utero embryonic development; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; cellular response to insulin stimulus; dephosphorylation; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; negative regulation of protein kinase activity; actin cytoskeleton organization and biogenesis; negative regulation of transcription, DNA-dependent