KATNA1 Antibody – Rabbit Polyclonal

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

KATNA1: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Hydrolase; EC 3.6.4.3

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; spindle pole; centrosome; microtubule; growth cone; cell soma; axon; cytoplasm; plasma membrane; microtubule organizing center; spindle; lipid particle; midbody; nucleus

Molecular Function: dynein binding; protein binding; protein heterodimerization activity; microtubule binding; microtubule-severing ATPase activity; ATP binding

Biological Process: mitosis; protein localization; metabolic process; cell division; microtubule severing; neuron migration; microtubule bundle formation; cytoplasmic microtubule organization and biogenesis