Rabbit Anti-KRT1 Polyclonal Antibody – Cat# MBS415842

Cytokeratin 1 (KRT1) Antibody – Rabbit Polyclonal

Name: KRT1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS415842
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415842

MBS415842 is an antibody targeting KRT1. Also known as Anti-Cytokeratin 1 Antibody. Reactive in Human, Mouse, Rat. Not yet tested in other species.. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cytokeratin 1 (KRT1), Polyclonal Antibody

Full Product Name

Anti-Cytokeratin 1 Antibody

Product Gene Name

anti-KRT1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat. Not yet tested in other species.

Form/Format

Liquid

Purity/Purification

Peptide immunogen affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

66,039 Da

OMIM

113800

3D Structure

ModBase 3D Structure for P04264

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Rabbit polyclonal Cytokeratin-1 antibody was raised against a peptide from the intermediate residues of human Cytokeratin-1 protein.

Applications Tested/Suitable for anti-KRT1 antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-KRT1 antibody

Peptide ELISA titer: 1:10,000-1:80,000
Western blot analysis: 1:200-1:1000
Immunohistochemistry: 1:100-500
Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-KRT1 antibody

(1) Richardson,E.S., Lee,J.B., Hyde,P.H.et al.A novel mutation and large size polymorphism affecting the V2 domain of keratin 1 in an African-American family with severe, diffuse palmoplantar keratoderma of the ichthyosis hystrix Curth-Macklin type.J. Invest. Dermatol. 126 (1), 79-84 (2006)

Other Notes

Small volumes of anti-KRT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT1. It may not necessarily be applicable to this product.

NCBI GI #

355564263

NCBI Accession #

EHH20763.1

UniProt Primary Accession #

P04264

UniProt Secondary Accession #

P85925; P86104; Q14720; Q6GSJ0; Q9H298; B2RA01

NCBI Official Full Name

Cytokeratin-1

UniProt Protein Name

Keratin, type II cytoskeletal 1

UniProt Synonym Protein Names

67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1

Protein Family

Keratin

UniProt Gene Name

KRT1

UniProt Entry Name

K2C1_HUMAN

UniProt Comments for KRT1

K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: extracellular matrix; extracellular space; cytoskeleton; membrane; keratin filament; plasma membrane; nucleus

Molecular Function: protein binding; receptor activity; carbohydrate binding; structural molecule activity

Biological Process: retinal homeostasis; fibrinolysis; negative regulation of inflammatory response; response to oxidative stress; complement activation, lectin pathway; regulation of angiogenesis

Disease: Palmoplantar Keratoderma, Epidermolytic; Keratosis Palmoplantaris Striata Iii; Ichthyosis Hystrix, Curth-macklin Type; Palmoplantar Keratoderma, Nonepidermolytic; Epidermolytic Hyperkeratosis; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT1 antibody

Reference Product	PubMed Publications
CTNNB1 antibody	>9 publications with KRT1 and CTNNB1
FLG antibody	>2 publications with KRT1 and FLG
PLAUR antibody	>1 publications with KRT1 and PLAUR
IVL antibody	>1 publications with KRT1 and IVL
LEF1 antibody	>1 publications with KRT1 and LEF1
LOR antibody	>1 publications with KRT1 and LOR

Diseases associated with anti-KRT1 antibody

Disease Name	Pubmed Publications
Skin Neoplasms Antibodies	>45 publications with KRT1 and Skin Neoplasms
Hyperkeratosis, Epidermolytic Antibodies	>39 publications with KRT1 and Hyperkeratosis, Epidermolytic
Inflammation Antibodies	>31 publications with KRT1 and Inflammation
Hyperplasia Antibodies	>25 publications with KRT1 and Hyperplasia
Carcinoma, Squamous Cell Antibodies	>25 publications with KRT1 and Carcinoma, Squamous Cell
Keratoderma, Palmoplantar, Epidermolytic Antibodies	>21 publications with KRT1 and Keratoderma, Palmoplantar, Epidermolytic
Immune System Diseases Antibodies	>20 publications with KRT1 and Immune System Diseases
Necrosis Antibodies	>12 publications with KRT1 and Necrosis
Cell Transformation, Neoplastic Antibodies	>12 publications with KRT1 and Cell Transformation, Neoplastic
Lung Diseases Antibodies	>10 publications with KRT1 and Lung Diseases

Organs/Tissues associated with anti-KRT1 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>238 publications with KRT1 and Skin
Blood Antibodies	>55 publications with KRT1 and Blood
Mouth Antibodies	>28 publications with KRT1 and Mouth
Thymus Antibodies	>14 publications with KRT1 and Thymus
Lung Antibodies	>11 publications with KRT1 and Lung
Mammary Gland Antibodies	>7 publications with KRT1 and Mammary Gland
Brain Antibodies	>5 publications with KRT1 and Brain
Bladder Antibodies	>4 publications with KRT1 and Bladder
Uterus Antibodies	>3 publications with KRT1 and Uterus
Heart Antibodies	>2 publications with KRT1 and Heart