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FXR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415857

This gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript… More details

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Product Overview

Product Name
FXR1, Polyclonal Antibody
Full Product Name
Anti-FXR1 Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
59,920 Da
OMIM
600819
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
a 15 amino acid peptide from near the C terminal residues of human FXR1 protein.
Applications Tested/Suitable for anti-FXR1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-FXR1 antibody
Peptide ELISA titer: 1:1,000-1:5,000
Western blot analysis: 1:200-500
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-FXR1 antibody

Rabbit Anti-FXR1 Polyclonal Antibody – Cat# MBS415857

Product References and Citations for anti-FXR1 antibody

(1) Vasudevan,S. and Steitz,J.A. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell 128 (6), 1105-1118 (2007).

Other Notes

Small volumes of anti-FXR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FXR1 purchase

MBS415857 is an antibody targeting FXR1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FXR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Homo sapiens fragile X mental retardation, autosomal homolog 1 (FXR1), transcript variant 2, mRNA
NCBI Official Synonym Full Names
fragile X mental retardation, autosomal homolog 1
NCBI Official Symbol
FXR1
NCBI Official Synonym Symbols
FXR1P
UniProt Protein Name
Fragile X mental retardation syndrome-related protein 1
UniProt Gene Name
FXR1
UniProt Entry Name
FXR1_HUMAN
NCBI Protein Information
fragile X mental retardation syndrome-related protein 1; hFXR1p

NCBI Summary for FXR1

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FXR1

FXR1: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: polysome; costamere; membrane; cytoplasm; nucleolus

Molecular Function: mRNA binding; mRNA 3'-UTR binding; RNA binding

Biological Process: muscle development; apoptosis; negative regulation of translation; cell differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FXR1 antibody

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