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PINX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416014

MBS416014 is an antibody targeting PINX1. Reactive in Human. Host: Rabbit. Rabbit polyclonal PIH1D2 More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PINX1, Polyclonal Antibody
Full Product Name
Anti-PINX1 Antibody
Product Gene Name
anti-PINX1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
19,714 Da
OMIM
606505
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Raised against a recombinate human PIH1D2 protein 21-281aa (BC015479).
Applications Tested/Suitable for anti-PINX1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PINX1 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-PINX1 antibody

Rabbit Anti-PINX1 Polyclonal Antibody – Cat# MBS416014

Immunohistochemistry (IHC) #2 of anti-PINX1 antibody

Rabbit Anti-PINX1 Polyclonal Antibody, Immunohistochemistry (IHC) #2 – Cat# MBS416014

Product References and Citations for anti-PINX1 antibody

(1) Soohoo,C.Y., Shi,R., Lee,T.H.et al. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J. Biol. Chem. 286 (5), 3894-3906 (2011).

Other Notes

Small volumes of anti-PINX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PINX1. It may not necessarily be applicable to this product.

NCBI GI #
15930068
NCBI GeneID
54984
NCBI Accession #
BC015479
UniProt Secondary Accession #
Q548A5; Q6QWG9; Q7Z7J8; Q96QD7; Q9HBU7; Q9NWW2; B2R9B1
UniProt Related Accession #
Q96BK5
NCBI Official Full Name
Homo sapiens PIN2-interacting protein 1, mRNA
NCBI Official Synonym Full Names
PIN2/TERF1 interacting, telomerase inhibitor 1
NCBI Official Symbol
PINX1
NCBI Official Synonym Symbols
LPTL; LPTS
UniProt Protein Name
PIN2/TERF1-interacting telomerase inhibitor 1
UniProt Synonym Protein Names
Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Protein Family
PIN2/TERF1-interacting telomerase inhibitor
UniProt Gene Name
PINX1
UniProt Entry Name
PINX1_HUMAN
NCBI Protein Information
PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein; PIN2 interacting protein 1; PIN2-interacting protein 1; TRF1-interacting protein 1; hepatocellular carcinoma-related putative tumor suppressor; liver-related putative tumor suppressor; pin2-interacting protein X1; protein 67-11-3

UniProt Comments for PINX1

PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Inhibitor; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: nucleoplasm; kinetochore; nuclear chromosome; chromosome, telomeric region; intracellular membrane-bound organelle; mitochondrion; cytoplasm; nucleolus; spindle; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; negative regulation of telomerase activity; regulation of telomerase activity; telomere maintenance via telomerase; mitotic metaphase plate congression
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Research Articles on PINX1

1. Data confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PINX1 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram

Diseases associated with anti-PINX1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with PINX1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >7 publications with PINX1 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with PINX1 and Cell Transformation, Neoplastic
 Genital Diseases, Male Antibodies  >2 publications with PINX1 and Genital Diseases, Male
 Cardiovascular Diseases Antibodies  >2 publications with PINX1 and Cardiovascular Diseases
 Uterine Cervical Neoplasms Antibodies  >2 publications with PINX1 and Uterine Cervical Neoplasms
 Fetal Death Antibodies  >1 publications with PINX1 and Fetal Death
 Neoplasm Metastasis Antibodies  >1 publications with PINX1 and Neoplasm Metastasis
 Ovarian Diseases Antibodies  >1 publications with PINX1 and Ovarian Diseases

Organs/Tissues associated with anti-PINX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with PINX1 and Liver
 Stomach Antibodies  >6 publications with PINX1 and Stomach
 Lymph Antibodies  >4 publications with PINX1 and Lymph
 Lymph Node Antibodies  >4 publications with PINX1 and Lymph Node
 Brain Antibodies  >4 publications with PINX1 and Brain
 Embryonic Tissue Antibodies  >3 publications with PINX1 and Embryonic Tissue
 Heart Antibodies  >2 publications with PINX1 and Heart
 Lung Antibodies  >2 publications with PINX1 and Lung
 Prostate Antibodies  >2 publications with PINX1 and Prostate
 Ovary Antibodies  >1 publications with PINX1 and Ovary
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