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COPE Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416062

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
COPE, Polyclonal Antibody
Full Product Name
Anti-COPE Antibody
Product Gene Name
anti-COPE antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
28,773 Da
OMIM
606942
3D Structure
ModBase 3D Structure for O14579
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Recombinant protein
Applications Tested/Suitable for anti-COPE antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-COPE antibody
Optimal dilutions to be determined by researchers

Testing Data of anti-COPE antibody

Rabbit Anti-COPE Polyclonal Antibody – Cat# MBS416062

Other Notes

Small volumes of anti-COPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPE purchase

MBS416062 is an antibody targeting COPE. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COPE. It may not necessarily be applicable to this product.

NCBI GI #
48145889
NCBI GeneID
11316
NCBI Accession #
CAG33167.1
UniProt Primary Accession #
O14579
UniProt Secondary Accession #
O76097; Q6IBB8; Q9UGP6; A6NE29; A6NKA3
UniProt Related Accession #
O14579
GenBank Nucleotide #
NM_007263
NCBI Official Full Name
COPE
NCBI Official Synonym Full Names
coatomer protein complex, subunit epsilon
NCBI Official Symbol
COPE
NCBI Official Synonym Symbols
epsilon-COP
UniProt Protein Name
Coatomer subunit epsilon
UniProt Synonym Protein Names
Epsilon-coat protein; Epsilon-COP
Protein Family
Coatomer
UniProt Gene Name
COPE
UniProt Entry Name
COPE_HUMAN
NCBI Protein Information
coatomer subunit epsilon; coatomer epsilon subunit; epsilon coat protein; epsilon-coat protein

UniProt Comments for COPE

COPE: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the COPE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; Golgi apparatus; COPI vesicle coat; cytosol

Molecular Function: structural molecule activity

Biological Process: intra-Golgi vesicle-mediated transport; protein transport; ER to Golgi vesicle-mediated transport; COPI coating of Golgi vesicle; retrograde vesicle-mediated transport, Golgi to ER
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Research Articles on COPE

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPE antibody

 Reference Product  PubMed Publications
 UBC antibody  >175 publications with COPE and UBC
 COPA antibody  >3 publications with COPE and COPA

Pathways associated with anti-COPE antibody

 Products by Pathway  Pathway Diagram
 COPI Mediated Transport Pathway antibodies  COPI Mediated Transport Pathway Diagram
 Golgi To ER Retrograde Transport Pathway antibodies  Golgi To ER Retrograde Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with anti-COPE antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >17853 publications with COPE and Nervous System Diseases
 Death Antibodies  >5042 publications with COPE and Death
 Heart Diseases Antibodies  >2531 publications with COPE and Heart Diseases
 Breast Neoplasms Antibodies  >2360 publications with COPE and Breast Neoplasms
 Cognition Disorders Antibodies  >2039 publications with COPE and Cognition Disorders
 Lung Diseases Antibodies  >1583 publications with COPE and Lung Diseases
 Memory Disorders Antibodies  >1208 publications with COPE and Memory Disorders
 Kidney Diseases Antibodies  >963 publications with COPE and Kidney Diseases
 Myocardial Infarction Antibodies  >716 publications with COPE and Myocardial Infarction
 Hypertension Antibodies  >709 publications with COPE and Hypertension

Organs/Tissues associated with anti-COPE antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14249 publications with COPE and Brain
 Blood Antibodies  >4893 publications with COPE and Blood
 Eye Antibodies  >3921 publications with COPE and Eye
 Heart Antibodies  >3829 publications with COPE and Heart
 Muscle Antibodies  >1942 publications with COPE and Muscle
 Nerve Antibodies  >1666 publications with COPE and Nerve
 Skin Antibodies  >1603 publications with COPE and Skin
 Kidney Antibodies  >1258 publications with COPE and Kidney
 Lung Antibodies  >1144 publications with COPE and Lung
 Bone Antibodies  >1064 publications with COPE and Bone
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