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ADAMTS8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416065

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a… More details

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Product Overview

Product Name
ADAMTS8, Polyclonal Antibody
Full Product Name
Anti-Human ADAMTS8 Antibody
Product Gene Name
Product Synonym Names
Anti-ADAMTS8 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
96,460 Da
OMIM
605175
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Synthetic peptide conjugated to KLH
Applications Tested/Suitable for anti-ADAMTS8 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ADAMTS8 antibody
Recommended dilutions:
Peptide ELISA: 1:80,000
WB: 1:500 - 1:1000
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-ADAMTS8 antibody

Rabbit Anti-ADAMTS8 Polyclonal Antibody – Cat# MBS416065

Product References and Citations for anti-ADAMTS8 antibody

Dunn,J.R., Reed,J.E., du Plessis,D.G., et al. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. Br. J. Cancer 94 (8), 1186-1193 (2006)

Other Notes

Small volumes of anti-ADAMTS8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAMTS8 purchase

MBS416065 is an antibody targeting ADAMTS8. Also known as Anti-Human ADAMTS8 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAMTS8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 8
NCBI Official Symbol
ADAMTS8
NCBI Official Synonym Symbols
METH2; ADAM-TS8
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 8
UniProt Synonym Protein Names
METH-2; METH-8
UniProt Gene Name
ADAMTS8
UniProt Entry Name
ATS8_HUMAN
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 8; ADAM-TS 8; ADAMTS-8; METH-2; METH-8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8

NCBI Summary for ADAMTS8

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
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UniProt Comments for ADAMTS8

ADAMTS8: Has anti-angiogenic properties.

Protein type: Secreted; Protease; Cell cycle regulation; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; low affinity phosphate transmembrane transporter activity

Biological Process: negative regulation of cell proliferation; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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