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Cathepsin D (CTSD) ELISA Kit for Fish

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS041612

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies… More details

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Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cathepsin D (CTSD), ELISA Kit
Full Product Name
Fish Cathepsin D ELISA Kit
Product Gene Name
CTSD elisa kit
Species Reactivity
Fish
Assay Type
Sandwich
Samples
Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids
Detection Range
15.6 pg/ml – 500 pg/ml.
Sensitivity
2.0 pg/ml.
Specificity
No significant cross-reactivity or interference between Fish CTSD and analogues was observed.
Preparation and Storage
Store all reagents at 2-8 degree C
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Molecular Weight
44,552 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (1773982..1785222, complement). Location: 11p15.5
OMIM
116840
3D Structure
ModBase 3D Structure for P07339

Typical Testing Data/Standard Curve (for reference only) of CTSD elisa kit

Fish CTSD ELISA Kit – Cat# MBS041612

Other Notes

Small volumes of CTSD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSD purchase

MBS041612 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cathepsin D (CTSD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CTSD. The ELISA analytical biochemical technique of the MBS041612 kit is based on CTSD antibody-CTSD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CTSD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CTSD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CTSD. It may not necessarily be applicable to this product.

NCBI GI #
48146011
NCBI GeneID
1509
NCBI Accession #
CAG33228.1
UniProt Primary Accession #
P07339
UniProt Secondary Accession #
Q6IB57
UniProt Related Accession #
P07339
NCBI Official Full Name
CTSD
NCBI Official Synonym Full Names
cathepsin D
NCBI Official Symbol
CTSD
NCBI Official Synonym Symbols
CPSD; CLN10
UniProt Protein Name
Cathepsin D
Protein Family
Aspartic-type endopeptidase
UniProt Gene Name
CTSD
UniProt Synonym Gene Names
CPSD
UniProt Entry Name
CATD_HUMAN
NCBI Protein Information
cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10

NCBI Summary for CTSD

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
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UniProt Comments for CTSD

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Motility/polarity/chemotaxis; Autophagy; EC 3.4.23.5; Protease

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; lysosome; extracellular region; melanosome

Molecular Function: protein binding; aspartic-type endopeptidase activity

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10
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Research Articles on CTSD

1. The beta-hairpin loop of human pro-cathepsin D, absent in the zebrafish protein, acts as recognition peptide for the enzymes involved in post translational processing.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSD elisa kit

 Reference Product  PubMed Publications
 CTSB elisa kit  >22 publications with CTSD and CTSB
 TP53 elisa kit  >3 publications with CTSD and TP53
 CTSS elisa kit  >2 publications with CTSD and CTSS
 ESR1 elisa kit  >1 publications with CTSD and ESR1

Pathways associated with CTSD elisa kit

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram

Diseases associated with CTSD elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >51 publications with CTSD and Nervous System Diseases
 Brain Diseases Antibodies  >46 publications with CTSD and Brain Diseases
 Neoplasms Antibodies  >41 publications with CTSD and Neoplasms
 Disease Models, Animal Antibodies  >18 publications with CTSD and Disease Models, Animal
 Inflammation Antibodies  >13 publications with CTSD and Inflammation
 Liver Diseases Antibodies  >10 publications with CTSD and Liver Diseases
 Breast Neoplasms Antibodies  >9 publications with CTSD and Breast Neoplasms
 Drug Toxicity Antibodies  >9 publications with CTSD and Drug Toxicity
 Necrosis Antibodies  >7 publications with CTSD and Necrosis
 Cardiovascular Diseases Antibodies  >6 publications with CTSD and Cardiovascular Diseases

Organs/Tissues associated with CTSD elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with CTSD and Blood
 Brain Antibodies  >27 publications with CTSD and Brain
 Liver Antibodies  >17 publications with CTSD and Liver
 Muscle Antibodies  >16 publications with CTSD and Muscle
 Lung Antibodies  >11 publications with CTSD and Lung
 Kidney Antibodies  >9 publications with CTSD and Kidney
 Vascular Antibodies  >8 publications with CTSD and Vascular
 Eye Antibodies  >6 publications with CTSD and Eye
 Bone Antibodies  >6 publications with CTSD and Bone
 Nerve Antibodies  >4 publications with CTSD and Nerve
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