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IMPA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416126

MBS416126 is an antibody targeting IMPA2. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit. Rabbit Polyclonal Antibody More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IMPA2, Polyclonal Antibody
Full Product Name
Anti-IMPA2 Antibody
Product Gene Name
anti-IMPA2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
28,512 Da
OMIM
605922
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Raised against a recombinate human IMPA2 protein 16-230aa (BC017176)
Applications Tested/Suitable for anti-IMPA2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IMPA2 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Optimal dilutions/concentrations should be determined by the end user

Western Blot (WB) of anti-IMPA2 antibody

Rabbit Anti-IMPA2 Polyclonal Antibody – Cat# MBS416126

Product References and Citations for anti-IMPA2 antibody

Bloch,P.J., Weller,A.E., Doyle,G.A., et al. Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 34 (8), 1515-1519 (2010)

Other Notes

Small volumes of anti-IMPA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPA2. It may not necessarily be applicable to this product.

NCBI GI #
16877898
NCBI GeneID
3613
NCBI Accession #
BC017176
UniProt Secondary Accession #
Q9UJT3; B0YJ29
UniProt Related Accession #
O14732
NCBI Official Full Name
Homo sapiens inositol(myo)-1(or 4)-monophosphatase 2, mRNA
NCBI Official Synonym Full Names
inositol(myo)-1(or 4)-monophosphatase 2
NCBI Official Symbol
IMPA2
UniProt Protein Name
Inositol monophosphatase 2
UniProt Synonym Protein Names
Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2
UniProt Gene Name
IMPA2
UniProt Entry Name
IMPA2_HUMAN
NCBI Protein Information
inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2; myo-inositol monophosphatase A2

NCBI Summary for IMPA2

This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

UniProt Comments for IMPA2

IMPA2: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.25; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; metal ion binding; inositol-1(or 4)-monophosphatase activity

Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol biosynthetic process; inositol phosphate dephosphorylation; signal transduction; phosphate metabolic process
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Research Articles on IMPA2

1. results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IMPA2 antibody

 Reference Product  PubMed Publications
 IMPA1 antibody  >12 publications with IMPA2 and IMPA1
 INPP1 antibody  >1 publications with IMPA2 and INPP1

Pathways associated with anti-IMPA2 antibody

 Products by Pathway  Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-IMPA2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >6 publications with IMPA2 and Brain Diseases
 Seizures, Febrile Antibodies  >5 publications with IMPA2 and Seizures, Febrile
 Learning Disorders Antibodies  >1 publications with IMPA2 and Learning Disorders

Organs/Tissues associated with anti-IMPA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with IMPA2 and Brain
 Blood Antibodies  >5 publications with IMPA2 and Blood
 Kidney Antibodies  >3 publications with IMPA2 and Kidney
 Skin Antibodies  >1 publications with IMPA2 and Skin
 Intestine Antibodies  >1 publications with IMPA2 and Intestine
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