Rabbit Anti-POLDIP3 Polyclonal Antibody – Cat# MBS416131

POLDIP3 Antibody – Rabbit Polyclonal

Name: POLDIP3 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416131
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416131

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

POLDIP3, Polyclonal Antibody

Full Product Name

Anti-POLDIP3 Antibody

Product Gene Name

anti-POLDIP3 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human. Predicted: Mouse, Rat

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

42,895 Da

OMIM

611520

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Rabbit polyclonal POLDIP3 (1) antibody was raised against a recombinated human POLDIP3 protein 4-149aa (BC019643).

Applications Tested/Suitable for anti-POLDIP3 antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-POLDIP3 antibody

ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-POLDIP3 antibody

(1) Ma,X.M., Yoon,S.O., Richardson,C.J., et al. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133 (2), 303-313 (2008).

Other Notes

Small volumes of anti-POLDIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLDIP3 purchase

MBS416131 is an antibody targeting POLDIP3. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for POLDIP3. It may not necessarily be applicable to this product.

NCBI GI #

18043106

NCBI GeneID

84271

NCBI Accession #

BC019643

UniProt Secondary Accession #

Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9NSP5; Q9NSP6; A8K6F8; A8K6V9

UniProt Related Accession #

Q9BY77

NCBI Official Full Name

Homo sapiens polymerase (DNA-directed), delta interacting protein 3, mRNA

NCBI Official Synonym Full Names

polymerase (DNA-directed), delta interacting protein 3

NCBI Official Symbol

POLDIP3

NCBI Official Synonym Symbols

SKAR; PDIP46

UniProt Protein Name

Polymerase delta-interacting protein 3

UniProt Synonym Protein Names

46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR

Protein Family

Polymerase delta-interacting protein

UniProt Gene Name

POLDIP3

UniProt Entry Name

PDIP3_HUMAN

NCBI Protein Information

polymerase delta-interacting protein 3; 46 kDa DNA polymerase delta interaction protein; RNA-binding protein P46; S6K1 Aly/REF-like target

UniProt Comments for POLDIP3

SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck

Molecular Function: protein binding; nucleotide binding

Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation

Research Articles on POLDIP3

1. these findings establish critical and essential roles for SKAR in the regulation of mRNA translation of IFN-sensitive genes and induction of IFN-alpha biological responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POLDIP3 antibody

Reference Product	PubMed Publications
ERH antibody	>2 publications with POLDIP3 and ERH

Pathways associated with anti-POLDIP3 antibody

Products by Pathway	Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram

Diseases associated with anti-POLDIP3 antibody

Disease Name	Pubmed Publications
Death Antibodies	>2 publications with POLDIP3 and Death
Inflammation Antibodies	>1 publications with POLDIP3 and Inflammation
Kidney Diseases Antibodies	>1 publications with POLDIP3 and Kidney Diseases

Organs/Tissues associated with anti-POLDIP3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with POLDIP3 and Brain
Blood Antibodies	>3 publications with POLDIP3 and Blood
Vascular Antibodies	>1 publications with POLDIP3 and Vascular
Kidney Antibodies	>1 publications with POLDIP3 and Kidney
Lung Antibodies	>1 publications with POLDIP3 and Lung