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DCP1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416192

Decapping is a key step in general and regulated mRNA decay. This gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs… More details

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Product Overview

Product Name
Dcp1a, Polyclonal Antibody
Full Product Name
Anti-Dcp1a Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
59,361 Da
OMIM
607010
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Synthetic peptide conjugated to KLH
Applications Tested/Suitable for anti-Dcp1a antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-Dcp1a antibody
Peptide ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:250-1000
Optimal dilutions/concentrations should be determined by the end user

Western Blot (WB) of anti-Dcp1a antibody

Rabbit Anti-DCP1A Polyclonal Antibody – Cat# MBS416192

Product References and Citations for anti-Dcp1a antibody

(1) Lykke-Andersen,J Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
Mol. Cell. Biol. 2002;22 (23),:8114-8121.

Other Notes

Small volumes of anti-Dcp1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dcp1a purchase

MBS416192 is an antibody targeting Dcp1a. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Dcp1a. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Homo sapiens decapping mRNA 1A (DCP1A), mRNA
NCBI Official Synonym Full Names
decapping mRNA 1A
NCBI Official Symbol
DCP1A
NCBI Official Synonym Symbols
SMIF; SMAD4IP1; HSA275986; Nbla00360
UniProt Protein Name
mRNA-decapping enzyme 1A
UniProt Synonym Protein Names
Smad4-interacting transcriptional co-activator; Transcription factor SMIF
Protein Family
UniProt Gene Name
DCP1A
UniProt Entry Name
DCP1A_HUMAN
NCBI Protein Information
mRNA-decapping enzyme 1A; DCP1 decapping enzyme homolog A; Smad4-interacting transcriptional co-activator; decapping enzyme hDcp1a; putative protein product of Nbla00360; transcription factor SMIF

NCBI Summary for Dcp1a

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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UniProt Comments for Dcp1a

DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling.

Protein type: Hydrolase; RNA processing; Transcription, coactivator/corepressor; EC 3.-.-.-

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: membrane; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; hydrolase activity

Biological Process: mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA catabolic process, deadenylation-dependent decay
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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