ABCE1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Ref.7 Ref.8 Ref.9

Subunit structure: Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.

Subcellular location: Cytoplasm. Mitochondrion. Note: Localized to clusters of virus formation at the plasma membrane. Ref.9

Induction: Activated by encephalomyocarditis virus (EMCV) and HIV-1. Ref.7 Ref.8

Miscellaneous: The ABC transporter domains seem not to be functional.

Sequence similarities: Belongs to the ABC transporter superfamily. ABCE family.Contains 2 4Fe-4S ferredoxin-type domains.Contains 2 ABC transporter domains.